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设计和合成了两亲性树枝状药物载体化合物6-Arm MPEG-Drug Conjugate,其中所使用的模型药物分子为苯甲酸.用1H NMR和13C NMR测试对结构进行了表征. 1H NMR谱图表明载体化合物在有机溶剂和水中表现不同的聚集行为,在水中自组装形成纳米微粒.利用荧光探针技术、动态激光光散射和扫描电镜研究其在水中的胶束化行为.结果显示,该药物载体化合物具有很低的临界胶束浓度,2.5×10-2 mg/mL (5.3×10-6 mol/L);在水溶液中浓度为1.0 mg/mL时的流体力学直径为67.4 nm,多分散指数为0.106;通过扫描电镜观察发现,初始浓度不同形成的聚集体形态也不同,得到了管状和方形结构胶束,而且随着不同水量的加入,聚集态从管状转变为囊泡状结构. 相似文献
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Gulnara Gaynanova Leysan Vasileva Ruslan Kashapov Darya Kuznetsova Rushana Kushnazarova Anna Tyryshkina Elmira Vasilieva Konstantin Petrov Lucia Zakharova Oleg Sinyashin 《Molecules (Basel, Switzerland)》2021,26(22)
This review focuses on key topics in the field of drug delivery related to the design of nanocarriers answering the biomedicine criteria, including biocompatibility, biodegradability, low toxicity, and the ability to overcome biological barriers. For these reasons, much attention is paid to the amphiphile-based carriers composed of natural building blocks, lipids, and their structural analogues and synthetic surfactants that are capable of self-assembly with the formation of a variety of supramolecular aggregates. The latter are dynamic structures that can be used as nanocontainers for hydrophobic drugs to increase their solubility and bioavailability. In this section, biodegradable cationic surfactants bearing cleavable fragments are discussed, with ester- and carbamate-containing analogs, as well as amino acid derivatives received special attention. Drug delivery through the biological barriers is a challenging task, which is highlighted by the example of transdermal method of drug administration. In this paper, nonionic surfactants are primarily discussed, including their application for the fabrication of nanocarriers, their surfactant-skin interactions, the mechanisms of modulating their permeability, and the factors controlling drug encapsulation, release, and targeted delivery. Different types of nanocarriers are covered, including niosomes, transfersomes, invasomes and chitosomes, with their morphological specificity, beneficial characteristics and limitations discussed. 相似文献
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本文研究了烷基链不饱和度对吐温表面活性剂囊泡包载姜黄素的影响。相比吐温-80囊泡,吐温-60囊泡的包载使姜黄素表现出更大的紫外吸收和荧光发射强度、缔合常数和DPPH自由基清除能力。核磁共振氢谱结果表明姜黄素缔合于吐温-60囊泡双分子层中的亲水头基附近,而且姜黄素的酚羟基与吐温-60的酯基产生氢键作用。在吐温-80囊泡中,双键会使吐温-80烷基链产生弯曲或折叠,导致双分子层排列更加松散、极性更高。因此,姜黄素除了与吐温-80的酯基产生氢键作用外,还能与吐温-80烷基链尾部和中部的亚甲基发生作用。 相似文献
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Banafsheh Honarvari Sara Karimifard Niyayesh Akhtari Mehrnoush Mehrarya Zahra Salehi Moghaddam Mohammad Javed Ansari Abduladheem Turki Jalil Adrin Matencio Francesco Trotta Faten Eshrati Yeganeh Bahareh Farasati Far Mandana Kazem Arki Mohammad Reza Naimi-Jamal Hassan Noorbazargan Zahra Asghari Lalami Mohsen Chiani 《Molecules (Basel, Switzerland)》2022,27(14)
As the most common cancer in women, efforts have been made to develop novel nanomedicine-based therapeutics for breast cancer. In the present study, the in silico curcumin (Cur) properties were investigated, and we found some important drawbacks of Cur. To enhance cancer therapeutics of Cur, three different nonionic surfactants (span 20, 60, and 80) were used to prepare various Cur-loaded niosomes (Nio-Cur). Then, fabricated Nio-Cur were decorated with folic acid (FA) and polyethylene glycol (PEG) for breast cancer suppression. For PEG-FA@Nio-Cur, the gene expression levels of Bax and p53 were higher compared to free drug and Nio-Cur. With PEG-FA-decorated Nio-Cur, levels of Bcl2 were lower than the free drug and Nio-Cur. When MCF7 and 4T1 cell uptake tests of PEG-FA@Nio-Cur and Nio-Cur were investigated, the results showed that the PEG-FA-modified niosomes exhibited the most preponderant endocytosis. In vitro experiments demonstrate that PEG-FA@Nio-Cur is a promising strategy for the delivery of Cur in breast cancer therapy. Breast cancer cells absorbed the prepared nanoformulations and exhibited sustained drug release characteristics. 相似文献
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