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排序方式: 共有272条查询结果,搜索用时 31 毫秒
1.
Zhu XQ Cao L Liu Y Yang Y Lu JY Wang JS Cheng JP 《Chemistry (Weinheim an der Bergstrasse, Germany)》2003,9(16):3937-3945
Five 1-(p-substituted phenyl)-1,4-dihydronicotinamides (GPNAH-1,4-H(2)) and five 1-(p-substituted phenyl)-1,2-dihydronicotinamides (GPNAH-1,2-H(2)) were synthesized, which were used to mimic NAD(P)H coenzyme and its 1,2-dihydroisomer reductions, respectively. When the 1,4-dihydropyridine (GPNAH-1,4-H(2)) and the 1,2-dihydroisomer (GPNAH-1,2-H(2)) were treated with p-trifluoromethylbenzylidenemalononitrile (S) as a hydride acceptor, both reactions gave the same products: pyridinium derivative (GPNA(+)) and carbanion SH(-) by a hydride one-step transfer. Thermodynamic analysis on the two reactions shows that the hydride transfer from the 1,2-dihydropyridine is much more favorable than the hydride transfer from the corresponding 1,4-dihydroisomer, but the kinetic examination displays that the former reaction is remarkably slower than the latter reaction, which is mainly due to much more negative activation entropy for the former reaction. When the formed pyridinium derivative (GPNA(+)) was treated with SH(-), the major reduced product was the corresponding 1,4-dihydropyridine along with a trace of the 1,2-dihydroisomer. Thermodynamic and kinetic analyses on the hydride transfer from SH(-) to GPNA(+) all suggest that the 4-position on the pyridinium ring in GPNA(+) is much easier to accept the hydride than the 2-position, which indicates that when the 1,4-dihydropyridine is used the hydride donor to react with S, the formed pyridinium derivative GPNA(+) may return to the 1,4-dihydropyridine by a hydride transfer cycle; but when the 1,2-dihydropyridine is used as the hydride donor, the formed pyridinium derivative can not return to the 1,2-dihydropyridine by the hydride reverse transfer from SH(-) to GPNA(+). These results clearly show that the hydride-transfer cycle is favorable for the 1,4-dihydronicotinamides, but unfavorable for the corresponding 1,2-dihydroisomers. 相似文献
2.
配合物[Pd(phen)Cl2]与腺嘌呤的键合作用研究 总被引:1,自引:0,他引:1
合成并表征了固体三元配合物[Pd(phen)Cl2] 1. 以1和DNA的组成小分子腺嘌呤(ade)反应, 获得双核配合物单晶[Pd2(phen)2(ade)2]Cl2•4.5H2O (2). 配合物2为正交晶系, 空间群为Pnma, 晶胞参数a=2.1709(9) nm, b=1.4378(6) nm, c=1.2274(5) nm, α=β=γ=90°, V=3.8311(3) nm3, Dc=1.729 g/cm3, Z=4, F(000)=2004, R1=0.0766, wR2=0.1526. phen配体以两个氮原子与钯(II)离子配位, 按生物学原子规范标号, ade以N(3), N(9)原子与钯(II)离子桥联配位, 形成双核混配型配合物. 相似文献
3.
4.
毛细管区带电泳法测定冬虫夏草中的腺苷、腺嘌呤和尿嘧啶 总被引:9,自引:0,他引:9
建立了毛细管区带电泳法测定天然和人工冬虫夏草中腺苷、腺嘌呤和尿嘧啶含量的分析方法。采用15mmol/L硼砂+14mmol/L磷酸二氢钠+5%(V/V)甲醇(pH=9.5)作为缓冲体系,在电压为18kV和检测波长为254nm的条件下,冬虫夏草提取液中的腺苷、腺嘌呤和尿嘧啶实现了基线分离。定量分析表明,3种成分的校正峰面积与质量浓度呈较好的线性关系(r≥0.9991)。考察了缓冲溶液的pH值、浓度及有机改性剂对腺苷、腺嘌呤和尿嘧啶迁移行为的影响。 相似文献
5.
Daqing Wang Baoxue Zhou Yuanjang Jia Feng Shi Yiping Fan 《Journal of Thermal Analysis and Calorimetry》1995,45(1-2):221-226
The complex Mn(Nica)2Cl2 (Nica=nicotinamide) was prepared, and its decomposition was studied by means of TG and DSC. The IR spectra of the products
of thermal decomposition were examined at every stage. Kinetic analysis of the first stage of thermal decomposition was performed
via the TG-DTG curves, and the kinetic parameters were obtained from analysis of the TG-DTG curves with integral and differential
methods. The most probable kinetic function was suggested from a comparison of the kinetic parameters. Mathematical expressions
were derived for the kinetic compensation effect.
Zusammenfassung Der Komplex Mn(Nica)2Cl2 (Nica steht für Nikotinamid) wurde hergestellt und seine Zersetzung mittels TG und DSC untersucht. Die thermisch zersetzten Substanzen jedes Schrittes wurden mittels IR-Spektren untersucht. Anhand der TG-DTG-Kurven erstellte man eine kinetische Analyse des ersten Schrittes der thermischen Zersetzung, die kinetischen Parameter wurden aus den TG-DTG-Kurven unter Einsatz von Integrations- und Differentialmethoden ermittelt. Durch Vergleich der kinetischen Parameter wurde die wahrscheinlichste kinetische Funktion vorgeschlagen. Mathematische Ausdrücke für den kinetischen Kompensationseffekt wurden erhalten.相似文献
6.
7.
The solubility of the nucleic acid bases, adenine and thymine, in aqueous erythritol, xylose, glucose, and sucrose solutions has been studied. The solubility of adenine increases linearly with glucose and sucrose concentration, whereas with the other reagents a nonlinear increase is observed. Below 1.5M reagent concentration, the solubility of adenine increases in the order erythritol < robose, xylose < glucose < sucrose. The solubility of thymine in these solutions, on the other hand, decreases, increases, or does not change depending upon the reagent. The effect of temperature on the solubility of adenine and thymine in sugar solution indicates that the transfer of these molecules from water to sugar solution is exothermic.Presented in part at the VIIth All-India Symposium in Biophysics held at Visva Bharati University during October 1976. 相似文献
8.
Icbudak H. Heren Z. Kose D. Ali Necefoglu H. 《Journal of Thermal Analysis and Calorimetry》2004,76(3):837-851
The mixed-ligand p-hydroxybenzoate complexes of Ni(II), Cu(II) and Zn(II) with nicotinamide and N,N-diethylnicotinamide were synthesized and
characterized by elemental analysis, magnetic susceptibility measurements and mass spectrometry. The thermal behavior of the
complexes was studied by simultaneous TG, DTG and DTA methods in static air atmosphere. The infrared spectral characteristics
of the complexes are also discussed. The complexes contain two water molecules, two p-hydroxybenzoato (p-hba) and two nicotinamide (na) (or diethylnicotinamide (dena)) ligands per formula unit. In these complexes,
all ligands are coordinated to the metal ion as monodendate ligands. In Zn(II)-na and Cu(II)-dena complexes, thep-hydroxybenzoate behaves as bidentate chelating ligand through carboxylic oxygen atoms. The decomposition pathways and the
stability of the complexes are interpreted in the terms of the structural data. The final decomposition products were found
to be the respective metal oxides.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
9.
A strain ofRhodococcus equi SHB-121 forming 3-cyanopyridine hydratase was screened from nitrile-polluted soil. The optimum conditions for the formation
of 3-cyanopyridine hydratase by the strain SHB-121 have been studied. Under the optimum conditions, the specific activity
of the enzyme reached 5.32 U/mg of dry cell, 95 times higher than that cultured in screening medium. In addition, the activity
of coexistent amidase was very low.
3-Cyanopyridine hydratase was purified from methylacrylamide-induced cells ofRh. equi SHB-121 by procedures including ultrasonic oscillation, ammonium sulfate precipitation, and column chromatographies on DEAE-cellulose
DE52, hydroxyapatite, and Sephadex G-25. The overall purification was 31-fold. The molecular weight of the enzyme was about
30 kDA by SDS-PAGE. The pI value was 4.1. The transition temperature and pH were 7.0°C and 6.0, respectively, resulting from
the differential spectra.
The optimum pH and temperature for the enzyme reaction were 8.0 and 30°C. The enzyme activity was strongly inhibited by Ag+, Hg2+, Cu2+, and NH4
+, whereas it was enhanced by Fe3+ slightly. The enzyme catalyzed the hydration of 3-cyanopyridine to nicotinamide, and itsKm value was 0.1 mol/L. Uncompetitive inhibitor sodium cyanide has a K, value of 5 mmol/L. 相似文献
10.