Natural Polyphenol–Vanadium Oxide Nanozymes for Synergistic Chemodynamic/Photothermal Therapy

The selection of suitable nanozymes with easy synthesis, tumor specificity, multifunction, and high therapeutics is meaningful for tumor therapy. Herein, a facile one-step assembly approach was employed to successfully prepare a novel kind of natural polyphenol tannic acid (TA) hybrid with mixed valence vanadium oxide nanosheets (TA@VO_x NSs). In this system, VO_x is assembled with TA through metal–phenolic coordination interaction to both introduce superior peroxidase-like activity and high near infrared (NIR) absorption owing to partial reduction of vanadium from V⁵⁺ to V⁴⁺. The presence of mixed valence vanadium oxide in TA@VO_x NSs is proved to be the key for the catalytic reaction of hydrogen peroxide (H₂O₂) to ^. OH, and the corresponding catalytic mechanism of H₂O₂ by TA@VO_x NSs is proposed. Benefitting from such peroxidase-like activity of TA@VO_x NSs, the overproduced H₂O₂ of the tumor microenvironment allows the realization of tumor-specific chemodynamic therapy (CDT). As a valid supplement to CDT, the NIR absorption enables TA@VO_x NSs to have NIR light-mediated conversion ability for photothermal therapy (PTT) of cancers. Furthermore, in vitro and in vivo experiments confirmed that TA@VO_x NSs can effectively inhibit the growth of tumors by synergistic CDT/PTT. These results offer a promising way to develop novel vanadium oxide-based nanozymes for enhanced synergistic tumor-specific treatment.