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The study employed isothermal
titration calorimetry (ITC) technique to investigate the interactions between
a skin penetration enhancer, laurocapram, and three representatives of the
human stratum corneum (SC) intercellular lipids, i.e., ceramide-3, cholesterol
and behenic acid. Experiments were performed using a TAM2277 (Thermometric
AB, Sweden) calorimeter. Results showed that, firstly, two laurocapram molecules
were bound to one ceramide-3 molecule in propylene glycol solution. The binding
was enthalpy-driven and system entropy decreased after binding. Secondly,
the binding ratio between cholesterol and laurocapram molecule was one to
one. It was mainly an entropy-driven process, suggesting the ordered cholesterol
molecules in SC lamella were disturbed by the introduction of laurocapram.
Hydrogen bonding might be the main force of the binding. The three different
interaction modes showed that the chemical enhancers selectively interacted
with the components of SC lipids so that the SC can still retain its barrier
function. 相似文献
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