Molecular Structure of γ-Apienes. Crystal and Molecular Structure of Ferocin

The molecular structure of the sesquiterpene humulene ester ferocin isolated from plants of the Ferula genus was determined by x-ray structure analysis. The conformation of the 11-membered γ-humulene ring was analyzed by molecular mechanics. It was found that four energetically similar macrocycle conformations are characteristic of γ-apienes.__________Translated from Khimiya Prirodnykh Soedinenii, No. 2, pp. 125–128, March–April, 2005.     

Humulene Diepoxides from the Australian Arid Zone Herb Dysphania: Assignment of Aged Hops Constituents

Dysphania is an abundant genus of plants, many of which are endemic to the Australian continent, occurring primarily in arid and temperate zones. Despite their prevalence, very few investigations into the phytochemistry of native Dysphania have been undertaken. Described herein, is the isolation and elucidation of two enantiomeric diastereomers of humulene diepoxide C from D. kalpari and D. rhadinostachya, of which unassigned diastereomers of humulene diepoxide C have been previously reported as components in beer brewed from aged hops. In addition, two (+)-humulene diepoxiols (humulene diepoxiol C-I and C-II) were isolated from D. rhadinostachya. Analysis of Chinook hops oil confirmed the presence of both humulene diepoxide C-I and C-II as trace components, and in turn enabled GC-MS peak assignment to the relative stereochemistry. Anticancer assays did not reveal any significant activity for the (+)-humulene diepoxides. Antifungal assays showed good activity against a drug-resistant strain of C. auris, with MIC₅₀ values of 8.53 and 4.91 μm obtained for (+)-humulene diepoxide C-I and C-II, respectively.