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设计并合成了结构为TPP-Lys(Acp-DOTA-Gd)-COOH(简称Gd-DOTA-TPP)的小分子磁共振探针,通过电转染的方式用探针标记人源脐带间充质干细胞(hMSCs).11.7 T磁共振成像(MRI)扫描结果表明,Gd-DOTA-TPP标记的hMSCs在细胞内Gd含量为9×109 Gd/cell时,T2加权信号强度即可低至背景信号强度,呈现较强暗信号.将Gd-DOTA-TPP标记的hMSCs移植入小鼠脑室,可明显提高移植干细胞在MRI设备上的检测灵敏度,检测限可低至103个细胞. 相似文献
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Ting Yu Chee Kai Chua Chor Yong Tay Feng Wen Haiyang Yu Jerry K. Y. Chan Mark S. K. Chong David Tai Leong Lay Poh Tan 《Macromolecular bioscience》2013,13(6):799-807
Human mesenchymal stem cells (MSCs) derived from various origins show varied differentiation capability. Recent work shows that cell shape manipulation via micropatterning can modulate the differentiation of bone‐marrow‐derived MSCs. Herein, the effect of micropatterning on the myogenesis of MSCs isolated from three different sources (bone marrow, fetal tissue, and adipose) is reported. All the well‐aligned cells, regardless of source, predominantly commit to myogenic lineage, as shown by the significant upregulation of myogenic gene markers and positive myosin heavy chain staining. It is demonstrated that our novel micropattern can be used as a generic platform for inducing myogenesis of MSCs from different sources and may also have the potential to be extended to induce other lineage commitment.
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