From Y- to Siamese-twin shaped glycolipids

Summary A set of Y-shaped and Siamese-twin shaped carbohydrate based glycolipids was investigated using polarising microscopy. The structure was changed from the normal type (1 head, two chains) to complex inverted structures (2 heads outside 1 to 3 chains in the middle part). The carbohydrate headgroup was changed from mono- to disaccharide; also the alkyl chain length was varied systematically. The compounds displayed different thermotropic mesophases (Smectic A phases, columnar phases and cubic phases) depending on the type of carbohydrate headgroup and the alkyl chain length.     

聚乳酸-b-聚(N~ε-苄氧羰基-L-赖氨酸)-b-聚乙二醇的合成与表征

用端氨基聚乳酸做引发剂,在DMF中引发Nε-苄氧羰基-L-赖氨酸酐(Lys(Z)-NCA)聚合,合成了端氨基聚(Nε-苄氧羰基-L-赖氨酸)-b-聚乳酸两嵌段共聚物.以端羧基聚乙二醇经NHS活化与端氨基聚(Nε-苄氧羰基-L-赖氨酸)-b-聚乳酸偶联,合成了聚(乳酸-b-Nε-苄氧羰基-L-赖氨酸-b-乙二醇)三嵌段聚合物.利用IR、1H-NMR、GPC和TEM对它们的结构、形态进行了表征,结果表明,所合成的分子量可控、分子量分布窄(Mw/Mn=1.07)的嵌段共聚物,酰化反应产率达70%以上.同时聚乙二醇和Nε-苄氧羰基-L-赖氨酸被引入到聚乳酸主链中,在聚合物侧链脱保护后有望改善聚乳酸的细胞亲和性。     

基于计算机模拟的拟糖三肽的设计与合成

基于噬菌体展示的结果,对三种拟糖多肽与葡糖淀粉酶的相互作用进行了分子动力学模拟．计算机模拟结果表明,多肽N-端碱性氨基酸残基可与酶的活性中心结合．在此基础上,设计并用液相法合成了3个三肽(RSA,KSA,RCA),用于制备与葡糖淀粉酶或α-淀粉酶的复合物的晶体．     

多效价树枝状糖苷配体的合成

许多生命过程如细胞间的识别、信号传递等通常依赖于细胞表面的多个配体和受体的协同作用.多效价树枝状糖基配体的合成是研究生物体内蛋白质与糖类、糖类与糖类相互作用的重要途径.本文综述了多效价树枝状糖基配体这类合成配体的最新研究进展,包括以树枝状聚合物、环糊精、糖环、芳烃和大环等为框架的多效价树枝状糖基配体的合成.     

Glycopolymers and Glyco‐nanoparticles in Biomolecular Recognition Processes and Vaccine Development

With advances in polymerization techniques as well as selective chemical modification of carbohydrates, glycopolymers and glyco‐nanoparticles are emerging as an important class of materials with tailored properties or novel nanotechnology‐based platforms for a number of applications. The field of the so‐called glyco‐nanotechnology is starting to show some promises for future clinical applications. Glyco‐nanoparticles, due to their versatile nature, could offer a platform for the design of carbohydrate‐based vaccines and possibly allow the development of new single‐dose vaccines in disease areas of unmet need. This paper surveys the emerging roles of carbohydrate‐based polymeric and nanomaterials for biomolecular recognition processes and vaccine development.