Two New Eremophilenolides from Cacalia pilgeriana

Two new eremophilenolides, 1β-hydroxy-2β-methylsenecioyloxyeremophil-7 （11）-en- 8β （12）-olide （1）, 1β-hydroxy-2β-methylsenecioyloxy-8α-methoxyeremophil-7 （11）-en-8β （12）- olide （2）, were isolated from the roots of Cacalia pilgeriana. Their structures were elucidated by spectroscopic methods and X-ray diffraction analysis.     

Two New Eremophilenolides from Ligularia tongolensis

Chemical investigation of L. tongolensis afforded two new eremophilenolides, which were identified as 3β-（2＇-methylbutanoyloxy）-8βH-eremophil-7（11）-en-12, 8α（14, 6α）-diolide （1）and 8βH-eremophil-3, 7（11）-dien-12, 8α （14, 6α）-diolide （2）. Their structures were established by spectroscopic methods including 2D NMR experiments.     

A New Highly Oxygenated Eremophilenolide from Ligulariopsis shichuana

a new highly oxygenated eremophilenolide was isolated from Ligulariopsis shichuana. Its structure was elucidated by NMR spectroscopic and X-ray diffraction methods.     

Two New Eremophilenolides from Ligularia sagitta

Chemical investigation of L.sagitta afforded two new eremophilenolides, which were identified as 6β-angeloyloxy-10β-hydroxy-8 β-methoxy-eremophil-7(11)-en-12, 8α-olide (1) and 6β, 8β-dimethoxy-10β-hydroxy-eremophil-7(11)-en-12, 8α-olide (2). Their structures were estab- lished by spectroscopic methods including 2D NMR experiments.     

Two New Eremophilenolides from Ligularia fischeri

Ligulariajischerihasl0ngbeenusedastraditi0naImedicinet0relievec0ugh,invig0ratethecircuIation0fbIo0dandst0ppain'.FromtheplantgrowinginShengnonaiia,Hubei-Chlna,t\v0neweremophiIen0lideshavebeenisolated.Comp0undlwasneedlecrystalsfrompetr0lether(60-9O'C),m.p.=148-l50'C.ItsformulawasdeterminedasC,,H,'O'by"C-NMRandDEPTspectrainaccordancewiththem0lecularionpeakm/z=280inEIMS.Thetypeofcarbonsignals(5xC,3xCH,4xCH,,4xCH,)(Table2)sh0wedithadabicyclicsesquiterpeneskeletonbearingameth0xy.ahemi-…