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Nancy E. Onway Jacqueline A. Fidanza Larry W. McLaughlin 《Phosphorus, sulfur, and silicon and the related elements》2013,188(1-4):27-30
Abstract The substitution of a non-bridging oxygen by sulfur in a DNA intemucleotidic phosphorus residue creates a nucleophilic site which is amenable to labeling by reporter groups such as fluorophores or spin labels. Placement of a single phosphorothioate diester at a selected position allows site-specific attachment of the reporter group. Incorporating a phosphorothioate at each and every intemucleotidic phosphorous linkage allows the incorporation of multiple reporter groups, ideally one for each nucleoside residue. 相似文献
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