字节全加器及其在无线电测控系统中的应用

对全加器概念进行了推广，并在此基础上给出了使用字节全加器网络的无线电抗干扰算法。通过在实际的无线电测控系统中的应用，结果表明该算法具有良好的无线电抗干扰效果。     

枸椽酸锗对小鼠免疫功能的影响

枸椽酸锗能明显提高小鼠血清溶血素抗体水平，增强二硝基氯苯（DNCB）致小鼠迟发型皮肤过敏反应。增加小鼠免疫器官胸腺和脾脏的重量，表明枸椽酸锗能增强小鼠体液免疫和细胞免疫水平。     

基于主动式时间反转镜的声呐目标强度测量研究

为提高目标强度测量过程中的抗噪声、混响以及浅海多途干扰性能,从军标文件中的目标强度测量方法以及主动式时间反转镜的基本原理出发,经过研究和推演,发现可将基于单阵元的主动式时间反转镜与相关器结合应用于目标强度测量过程,提出了一种新的目标强度测量方法。该方法利用了主动式时间反转镜的抗多途特性,使得测量具有抗多途的性能;利用噪声与信号的不相关特性,算法结合相关器起到了很好的抗随机噪声效果;混响中的体积混响是随机的,算法具有抗体积混响的性能。论文分别从理论仿真和水池实验验证了算法的有效性和正确性。     

Loganin Alleviates Gout Inflammation by Suppressing NLRP3 Inflammasome Activation and Mitochondrial Damage

Gout is a type of inflammatory arthritis caused by the deposition of monosodium uric acid (MSU) crystals in tissues. The etiology of gout is directly linked to the NLRP3 inflammasome, since MSU crystals are NLRP3 inflammasome activators. Therefore, we decided to search for a small-molecule inhibitor of the NLRP3 inflammasome for the prevention of gout inflammation. We found that loganin suppressed MSU crystals-induced caspase-1 (p20) and interleukin (IL)-1β production and apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) specks formation in mouse primary macrophages, showing its ability to inhibit the NLRP3 inflammasome. In an air pouch inflammation model, oral administration of loganin to mice prevented MSU crystals-induced production of mature IL-1β and IL-18 in air pouch exudates, resulting in decreased neutrophil recruitment. Furthermore, oral administration of loganin suppressed MSU crystals-induced gout inflammation in a mouse foot gout model, which was accompanied by the inhibition of the NLRP3 inflammasome. Loganin blocked de novo synthesis of mitochondrial DNA in air pouches and foot tissues injected with MSU crystals. Consistently, loganin prevented MSU crystals-induced mitochondrial damage in macrophages, as it increased mitochondrial membrane potential and decreased the amount of mitochondrial reactive oxygen species. These data demonstrate that loganin suppresses NLRP3 inflammasome activation by inhibiting mitochondrial stress. These results suggest a novel pharmacological strategy to prevent gout inflammation by blocking NLRP3 inflammasome activation and mitochondrial dysfunction.     

一种新颖的高灵敏度光纤光栅带宽调谐机构

设计了一种由一直梁和两个半圆拱组成的开口环结构,并将均匀光纤布拉格光栅斜贴于直梁中间的表面处。对两半圆拱施加与直梁方向平行的应力作用时,光纤光栅受到线性应力场的作用,光纤布拉格光栅即转化为啁啾光纤光栅。该机构实现了光纤光栅带宽的线性调谐,线性度高达0．9982,实验结果与理论分析一致。与以往的带宽调谐机构相比,该机构具有很高的应力灵敏度,在20N力的作用下,可产生约7nm的带宽反射,灵敏度达0．34nm／N。利用环境温度对带宽调谐无影响的特性,采用带宽编码技术,研制出具有温度自动补偿特性、高灵敏度的带宽调谐装置。     

Boosts in an Arbitrary Direction and Maximal Causal Velocities in a Deformed Minkowski Space

We discuss boosts in a deformed Minkowski space, i.e., a four-dimensional spacetime with metric coefficients depending on nonmetric coordinates (in particular on the energy). The general form of a boost in an arbitrary direction is derived in the case of space anisotropy. Two maximal trivector velocities are mathematically possible, an isotropic and an anisotropic one. However, only the anisotropic velocity has physical meaning, being invariant indeed under deformed boosts.     

Analysis of the cellular Aspergillus fumigatus proteome that reacts with sera from rabbits developing an acquired immunity after experimental aspergillosis

Invasive aspergillosis caused by the mould Aspergillus fumigatus is a life‐threatening lung or systemic infection in the immunocompromised host. In this study, a protective immune response against the disease was achieved in two infected rabbits, and the cellular fungal antigenic proteome that mediated such a response was investigated against the background of vaccine development efforts. Altogether, 59 different Aspergillus proteins were found becoming reactive in the course of the developing immunity, many of which are described in this context for the first time. These included proteins related to oxidative stress management, glycolysis and other metabolic pathways. As oxidative stress is suspected to be one of the major defense mechanisms, the results may indicate at least in part a continuous response of the pathogen to evade the host's immune system. In addition, proteins with suspected cell surface association or crucial function for fungal cell development were identified. As these antigens are newly recognized during the process of the developing immunoprotection, they may not only represent valuable infection markers but also importantly broaden the list of possible vaccine candidates.     

不同开关频率下电压控制升压变换器中的Hopf分岔分析

由于电压控制升压变换器的传统平均模型中没有包含开关频率,从而无法分析开关频率的大小对电压控制升压变换器中Hopf分岔的影响. 通过建立电压控制升压变换器的含有开关频率的改进平均模型,分析了开关频率对电压控制升压变换器中Hopf分岔的影响,并设计硬件电路,给出电路试验结果. 研究表明:采用电压控制升压变换器的改进平均模型,可以有效地分析不同开关频率对电压控制升压变换器中Hopf分岔的影响; 随着开关频率的减小,电压控制升压变换器更易于发生Hopf分岔. 关键词： 改进平均模型 电压控制升压变换器 开关频率