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The crystal structure of the title compound 2-[(P, P-Diphenoxy)phosphono(p-methyl)benzyl]-1, 2-benzisoselenazol-3(2H)-one, C27H22NO4PSe, was determined by single crystal X-ray diffraction. It crystallizes in the triclinic system, space group P(No. 2) with Mr=534.41, a=9.761(2), b=10.304(2), c=13.396(3), α=110.97(3), β=107.70(3). γ=90.02(3)°, V=1190(1) 3, Z=2, Dx=1.492 g/cm3, λ=0.71073, μ=1.6596 mm-1 and F(000)=544. The structure was solved by direct methods. The final R factor is 0.068 and Rw is 0.074 for 2500 unique observed reflections [I≥3σ(I)]. The results presented herein indicate that the selenium-containing bicyclic moiety is a coplanar structure and that two adjacent molecules are symmetrically linked to each other forming a dimer through the Se(1c)...O=P(1) bonding interaction with an intermolecular Se(1c)...O distance of 2.797 . 相似文献
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荧光法研究硒酶模型化合物消除.OH自由基的作用 总被引:5,自引:0,他引:5
利用Fenton反应产生的羟基自由基与苯甲酸生成具有荧光的羟化苯甲酸,用荧光法间接测定羟基自由基的含量.用荧光法研究新合成的5种硒酶模型化合物对羟基自由基的清除作用.结果表明,新合成的硒酶模型化合物对羟基自由基有良好的清除作用.该法具有简便、快速、灵敏等特点. 相似文献
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1mrnODUCnONBenzisoselenazolones(BISAs)representanewclassofanti--inflammatoryagentasanexampleofseleno-organiccompoundsintherapyofoxidativestresslinkedpathologicalconditions(li.Amongthem,ebselen(2--phenyl--1,2--benzisoselenazol-3(2H)--one,PZ51)hasbeenacceptedasthebestmimicOfGSH-Px(Zi.InadditiontoitsGSH--Px-likeactivityt'nvdro,ithasbeenreportedthatebselencaninhibit5liPOxygenaseandNOsynthase"',isomeriseLTB.toabiologicallyinactiveisomer[41andinhibitthemigrationofPMNLandSPLTintotheinf… 相似文献
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根据活性基团拼合原理, 用2-氯硒基苯甲酰氯和2-氨基-5取代-1,3,4-噻二唑缩合合成了10个新的2-(2-取代- 1,3,4-噻二唑-5-基)-苯并异硒唑-3(2H)-酮衍生物(6), 并通过IR, 1H NMR, ESI-MS和元素分析对其结构进行了确认, 采用CCK-8法测试了化合物抑制肿瘤细胞增殖活性. 结果表明, 化合物6h对人体肺癌细胞A-549, 化合物6a, 6b, 6d, 6e, 6f, 6g, 6h, 6j对人体乳腺癌细胞MCF-7, 化合物6a, 6b, 6d, 6e, 6f, 6g对人体肝癌细胞SSMC-7721抑制活性均强于阳性对照药依布硒啉, 且表现出一定的选择性, 具有进一步研究的潜在价值. 相似文献
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采用NADPH/GSSG还原酶为指示剂的偶合法测定了两类共7种新型苯并异硒唑酮氨基酸衍生物的GSH-Px活性.结果表明,所有模拟物均显示较好的GSH-Px样活性,并且具有明显的构-效关系. 相似文献
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1INTRODUCTIONInrecentyearsbiologicalyactiveorganoseleniumcompoundshavebeguntoat tractconsiderableinterestduetotheiruniqueandd... 相似文献
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