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Md. Umar Khan M. A. Baseer S. Ranjith Kumar M. Saravanakumar A. G. Prasannanjali P. Badarinadh Gupta 《合成通讯》2013,43(15):2241-2253
Balsalazide disodium (Colazide®) is an oral prodrug of mesalamine (5-aminosalicylic acid) and possesses anti-inflammatory properties. During the process development for balsalazide disodium, we observed eight impurities, namely des-β-alanine balsalazide, balsalazide β-alanine, balsalazide 3-isomer, decarboxy balsalazide, bis-azo salicylic acid, biphenyl-azo salicylic acid, bis-azo diacid, and bis-azo triacid. The present work describes the synthesis and characterization of these impurities. 相似文献
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