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Xiangjun Peng Xianyun Xu Shuangyang Chen Zeng Tian Liangxian Liu Qian Liu 《Tetrahedron》2018,74(13):1505-1512
A series of unsymmetrical arylureas was obtained by the one-pot method for reacting isatins with indoles incorporating primary amino moieties, a significant heterocyclic skeleton for diverse pharmaceutically active structures. The reaction proceeds through Cu(I)-catalyzed C2C3 bond of the ring-opening isatins and then expands the substrates in the optimum conditions. Furthermore, selected compounds 4b and 4k exhibit moderate to good anti-schistosomicidal activities. 相似文献
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ZOU Jian-Ping LU Zhong-E CHEN Ke-QianDepartment of chemistry Suzhou University Suzhou Jiangsu China 《中国化学》1995,13(4):358-362
Fourteen new 1-acyl-5-aryl biurets were synthesized by the reaction of aryl ureas with acylisocynantes. The latter was obtained from acyl chloride and lead cyanate in dichloromethane, using pyridine as catalyst. The structures of compounds 3a-n were confirmed by IR,1H NMR and MS spectra. 相似文献
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