Synthesis and antituberculotic activity of some new imidazo[4,5-b]pyridine derivatives

The reactions of 2-acetylimidazo[4,5-b]pyridine hydrazone with some alkyl-and arylisothiocyanates and some orthoesters were carried out. Various new derivatives of the titled compound such as thiosemicarbazones, ethoxymethylenehydrazones, and derivatives of the new pyrido-[3′,2′:4,5]imidazo[1,2-d][1,2,4]triazine ring system were obtained. Biological data for selected compounds are presented. Published in Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1571–1579, October, 2006.     

Synthesis of New Imidazo[4,5-b]pyridine Derivatives

New imidazo[4,5-b]pyridine derivatives with various substituents in the 2-position (,-unsaturated ketones, imines, ²-pyrazolines, pyrimidines, 1,2,3,4-tetrahydropyrimidines) and derivatives of the new pyrido[3',2':4,5]imidazo[1,2-d][1,2,4]triazine ring system were synthesized. Biological data for selected compounds are presented.     

4-hydroxy-2-quinolones. 40. Synthesis and biological properties of anilides of 1H-2-oxo-4-hydroxyquinoline-3-carboxylic acid

An improved method for the synthesis of anilides of 1H-2-oxo-4-hydroxyquinoline-3-carboxylic acid was proposed. Results of the study of antithyroid and anti-tuberculosis activity of the compounds synthesized are presented.For the Communication 39, see [1].National Pharmaceutical Academy of Ukraine, Kharkov 31002. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 203–206, February, 2000.