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Alshymaa Abdel-Rahman Gomaa Usama Ramadan Abdelmohsen Markus Krischke Martin J. Mueller Amira Samir Wanas 《Natural product research》2020,34(18):2612-2615
AbstractThe present study evaluates the chemical composition of Zinnia elegans and Gazania rigens based on their metabolomic profiles using liquid chromatography coupled with high-resolution mass spectrometry (LC‐HR-MS), alongside with the anti-infective activities of their ethanol extracts, as well as, different fractions. A significant difference was observed between the LC-MS profiles of the two plants such as, coumarins, sesquiterpene lactones and phenylethanoids which were characteristic for Z. elegans, while amides and phenolic acid derivatives were characteristic for G. rigens. These results highlight the chemical potential of Z. elegans and G. rigens. Furthermore, the ethyl acetate fraction of Z. elegans showed a significant antimalarial activity with IC50 values of 21.03 and 13.72?µg/mL against Plasmodium falciparum D6 and P. falciparum W2, respectively. 相似文献
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Dr. Ana Marta de Matos 《European journal of organic chemistry》2023,26(4):e202200919
With the rise of antimicrobial resistance (AMR), innovation in antibacterial drug research and development is urgently needed and strongly encouraged by the World Health Organization (WHO). Carbohydrates are valuable bioactive scaffolds to be explored in this context, and because of their unique multifunctionality, stereochemical diversity, and natural protein-binding profile, they come across as attractive starting materials for the synthesis of antimicrobial agents with innovative mechanisms of action (MoA). In this concise review, state-of-the-art methodologies for the synthesis of an array of promising and recently developed carbohydrate-based molecules with antibacterial activity are presented and discussed. By describing successful case studies as platforms for the scrutiny of carbohydrate modification and coupling approaches in organic chemistry, this work summarizes the latest research efforts in this area, ultimately encouraging the design and synthesis of new and much-needed glycoantibiotic leads for pharmaceutical development. 相似文献
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Oday T. Ali Wafaa S. Hassan Ahdab N. Khayyat Ahmad J. Almalki Mahmoud M. Sebaiy 《Molecules (Basel, Switzerland)》2021,26(1)
A suitable HPLC method has been selected and validated for rapid simultaneous separation and determination of four imidazole anti-infective drugs, secnidazole, omeprazole, albendazole, and fenbendazole, in their final dosage forms, in addition to human plasma within 5 min. The method suitability was derived from the superiority of using the environmentally benign solvent, methanol over acetonitrile as a mobile phase component in respect of safety issues and migration times. Separation of the four anti-infective drugs was performed on a Thermo Scientific® BDS Hypersil C8 column (5 µm, 2.50 × 4.60 mm) using a mobile phase consist of MeOH: 0.025 M KH2PO4 (70:30, v/v) adjusted to pH 3.20 with ortho-phosphoric acid at room temperature. The flow rate was 1.00 mL/min and maximum absorption was measured with UV detector set at 300 nm. Limits of detection were reported to be 0.41, 0.13, 0.18, and 0.15 µg/mL for secnidazole, omeprazole, albendazole, and fenbendazole, respectively, showing a high degree of the method sensitivity. The method of analysis was validated according to Food and Drug Administration (FDA)guidelines for the determination of the drugs, either in their dosage forms with highly precise recoveries, or clinically in human plasma, especially regarding pharmacokinetic and bioequivalence studies. 相似文献
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Ahmed Galal Osman Zulfiqar Ali Omer Fantoukh Vijayasankar Raman Ramsay S. T. Kamdem 《Natural product research》2020,34(5):683-691
AbstractFour ursane-type triterpenoid glycosides (1-4), two benzophenone glycosides (5 and 6), and one iridoid glucoside (7) were isolated and characterized from the dried roots of Vangueria agrestis. Compounds 1 (3-O-[α-L-rhamnopyranosyl-(1→2)-β-D-xylopyranosyl]pomolic acid 28-O-β-D-glucopyranosyl ester) and 5 (2-O-[β-D-apiofuranosyl-(1→6)-β-D-glucopyranosyl]-6,4′-dihydroxy-4-methoxy benzophenone) were found to be new metabolites. The identity of all compounds has been accomplished, primarily, based on 1 D and 2 D NMR and HRESMS analysis. Compounds 6 and 2, showed inhibitory effect against Trypanosoma brucei with IC50 22.3 µM for 6 and IC50 11.1 µM, IC90 12.3 µM for 2. 相似文献
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Wayne HayesHelen M.I Osborn Sadie D OsborneRobert A Rastall Barbara Romagnoli 《Tetrahedron》2003,59(40):7983-7996
The synthesis of a selection of multivalent arrays of mannose mono- and disaccharides, that are of potential use as anti-infective agents against enterobacteria infections, is described. 相似文献
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