排序方式: 共有1条查询结果,搜索用时 0 毫秒
1
1.
Nguyen Ngoc Thanh Luan Dr. Takuya Okada Dr. Naoki Toyooka 《European journal of organic chemistry》2023,26(12):e202300047
Betuphenone F ( 6 ) is a natural product isolated from the bark of Betula alnoides Ham. ex D. Don (Betulaceae) and structurally determined by S. Awale et al. in 2021. Betuphenone F ( 6 ) has the potential to be a new-generation anti-cancer agents based on anti-austerity, as it showed preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrient-deprived conditions (PC50 value of 4.9 μM). We succeeded in constructing the 2-oxabicyclo[3.3.1]nonane skeleton, which is a structural feature of betuphenone F ( 6 ), by exposing intermediate 9 to acid, and achieved the first total synthesis of rac-bethuphenone F ( 6 ) from phloroglucinol ( 7 ) in only three steps. 相似文献
1