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Yousry M. Issa Hosny Ibrahim Adel F. Shoukry Sabry K. Mohamed 《Mikrochimica acta》1995,118(3-4):257-263
Ion-association complexes of antazoline HCl [I], hydralazine HCl [II], amiloride HCl [III] and quinine sulphate [IV] with [Co(SCN)4]2– and [Co(NO2)6]3– were precipitated and the excess unreacted cobalt complex was determined. A new method using atomic emission and atomic absorption spectrometry for the determination of the above drugs in pure solutions and pharmaceutical preparations is given. The drugs can be determined in the ranges 0.3–3.0, 0.19–1.96, 0.3–3.0, and 0.78–7.82 mg/25 ml solutions of I, II, III, and IV, respectively, with mean relative standard deviations of 0.65–2.03 % and recovery values of 95.76–101.2% indicating high precision and accuracy. 相似文献
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Xiaotian Li Baoluo Wan Tong Yu Linxi Wang Lianqi Hao Maowen Guo 《Biomedical chromatography : BMC》2013,27(12):1595-1602
A reversed‐phase ion pair chromatography method with liquid–liquid extraction analytical method was developed and validated for the determination of antazoline hydrochloride in plasma and excreta of rat. The aim of our study was to characterize the preclinical pharmacokinetics and excretion profiles of antazoline hydrochloride in rats after intravenous injection at the dose of 10 mg/kg. Plasma and excreta samples were extracted with ethyl acetate, and phenacetin was used as the internal standard. The result showed that the method is suitable for the quantification of antazoline hydrochloride in plasma and excreta samples. Analysis of accuracy (90.89–112.33%), imprecision (<7.1%) and recovery (>82.5%) showed adequate values. After a single intravenous administration at 10 mg/kg to rats, plasma concentration profile showed a relative fast elimination proceeding with a terminal elimination half‐life of 3.53 h. Approximately 61.8 and 14.2% of the administered dose were recovered in urine and bile after 72 and 24 h post‐dosing respectively; 5.9% of the administered dose was recovered in feces after 72 h post‐dosing. The above results show that the major elimination route is urinary excretion. Copyright © 2013 John Wiley & Sons, Ltd. 相似文献
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An analytical method is described for the analysis of antazoline [2-(N-benzylanilinomethyl) imidazoline] using pmr. The procedure provides good quantitative results together with a very specific mean for identification of antazoline 相似文献
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Barbara Marciniec M. Kozak M. Naskrent K. Dettlaff M. Ogrodowczyk M. Stawny L. Wachowski 《Journal of Thermal Analysis and Calorimetry》2007,88(2):337-342
Four imidazoline
derivatives: antazoline (AN), naphazoline (NN), tymazoline (TM), xylometazoline
(XM), in the form of hydrochlorides in solid phase have been subjected to
high energy e-beam irradiation from an accelerator (~10 MeV) at a dose varied
from 25 to 200 kGy. The effects of the irradiation have been assessed by DSC,
X-ray diffraction, FTIR, EPR and TLC.
The standard sterilisation
dose of 25 kGy has been found to produce changes in the properties of one
derivative (XM), two other ones (AN and TM) have been found sensitive to doses
>100 kGy, whereas NN has been resistant to irradiation in the whole range
studied (25–200 kGy). EPR results indicated that the changes taking
place in the therapeutic substances studied are related to radical formation.
The irradiation induced changes in colour, a decrease or increase in the melting
point, changes in the XRD pattern, small changes in the shape of FTIR peaks
and the presence of radiolysis products. The XM compounds cannot be sterilised
by irradiation because of the radiation induced changes in its physico-chemical
properties. 相似文献
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《Analytical letters》2012,45(8):1361-1370
Abstract A rapid HPLC method has been presented for the determination of some 2-imidazolines in several liquid or semi-solid commercial preparations. Two of the active ingredients were determined simultaneously whereas others were determined in the presence of dexamethasone and excipients. From the sample solutions no interference was observed on the chromatograms. Linearity and precision of the method have been assessed. The assay results obtained for various formulations were in accord with the declared amount. 相似文献
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