Spurenbestimmung ?strogenwirkender Masthilfsmittel in Fleisch durch HPLC mit voltammetrischer Detektion

Zusammenfassung Das voltammetrische und chromatographische Verhalten der Östrogene: Östriol, Östron, Östradiol, Diäthylstilböstrol, Dienöstrol und Hexöstrol sowie der Pseudoöstrogene Zeranol und Zearalenon wurde untersucht. Auf Grund der leichten Oxidierbarkeit der phenolischen Gruppe erlaubt die Kombination »Voltammetrische Detektion/Hochleistungs-Chromatographie« den hochempfindlichen, schnellen und routinemäßigen Nachweis dieser Masthilfsmittel in biologischem Material (Fleisch, Urin, Futtermittel). Chromatographisch nicht trennbare Östrogene (Diäthylstilböstrol/Hexöstrol) lassen sich dabei auf Grund ihrer verschiedenen Oxidationspotentiale elektrochemisch voneinander trennen.

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Determination of traces of estrogenic growth-promoting hormones in meat by HPLC with voltammetric detection

Summary The voltammetric and chromatographic behaviour of the growth-promoting hormones estriol, estrone, estradiol, diethylstilbestrol, dienestrol, hexestrol, zeranol and zearalenone has been investigated. It has been revealed that the voltammetric responses are most suitable for analytical purposes. Based on these findings a highly sensitive, rapid and convenient method has been developed for their determination in meat by high-performance liquid chromatography with voltammetric detection. In certain cases this method offers additional potentialities for the determination of otherwise non-separable substances having sufficiently differing oxidation potentials.

Abgeordnet vom Institut für Fundamentale Probleme der Chemie, Universität Warschau, im Rahmen des gemeinsamen Forschungsprojektes »Toxische Metalle in der Umwelt«     

A Stretchable Electrochemical Sensor for Inducing and Monitoring Cell Mechanotransduction in Real Time

Existing methods offer little direct and real‐time information about stretch‐triggered biochemical responses during cell mechanotransduction. A novel stretchable electrochemical sensor is reported that takes advantage of a hierarchical percolation network of carbon nanotubes and gold nanotubes (CNT‐AuNT). This hybrid nanostructure provides the sensor with excellent time‐reproducible mechanical and electrochemical performances while granting very good cellular compatibility, making it perfectly apt to induce and monitor simultaneously transient biochemical signals. This is validated by monitoring stretch‐induced transient release of small signaling molecules by both endothelial and epithelial cells cultured on this sensor and submitted to stretching strains of different intensities. This work demonstrates that the hybrid CNT‐AuNT platform offers a versatile and highly sensitive way to characterize and quantify short‐time mechanotransduction responses.