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Coenzyme Q10 (CoQ10) is the prevalent ubiquinone in human organism, largely present in its reduced form, ubiquinol (QH2), to which the antioxidant, free radical scavenger activity is ascribed by many authors. However, some studies indicate that also the oxidized form presents some effect in preventing the cellular oxidative stress. In this article four in vitro chemical test methods (TEAC, FRAP, DPPH, and BR) were used to assess the free radical scavenging power of CoQ10, QH2, and vitamin E. The results showed that CoQ10 is almost ineffective, while in three of the tests QH2 presents a higher antioxidant activity than vitamin E. From these results, it can be concluded that the interconversion CoQ10?QH2 leading to the prevalence of QH2 in biological tissues is responsible for the antioxidant action of coenzyme Q10 in living organisms. 相似文献
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Plastoquinone and ubiquinone play essential roles in the electron transport chains of chloroplasts and mitochondria by coupling electron transport to the transfer of protons across membranes. The energy of the resulting proton gradient is used to synthesize adenosine triphosphate (ATP), the energy currency of all life. How did quinones first become involved in this process? We have detected several quinone compounds in carbonaceous meteorites that can transport protons in a liposome model system. It is possible that such compounds were available to transport protons in primitive versions of electron transport in early life. 相似文献
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Naoya Kishikawa Nobuhiro Ohkubo Kaname Ohyama Kenichiro Nakashima Naotaka Kuroda 《Analytical and bioanalytical chemistry》2009,393(4):1337-1343
A sensitive and selective chemiluminescence assay for the determination of quinones was developed. The method was based on
generation of reactive oxygen species through the redox reaction between quinone and dithiothreitol as reductant, and then
the generated reactive oxygen was detected by luminol chemiluminescence. The chemiluminescence was intense, long-lived, and
proportional to quinone concentration. It is concluded that superoxide anion was involved in the proposed chemiluminescence
reaction because the chemiluminescence intensity was decreased only in the presence of superoxide dismutase. Among the tested
quinones, the chemiluminescence was observed from 9,10-phenanthrenequinone, 1,2-naphthoquinone, and 1,4-naphthoquinone, whereas
it was not observed from 9,10-anthraquinone and 1,4-benzoquinone. The chemiluminescence property was greatly different according
to the structure of quinones. The chemiluminescence was also observed for biologically important quinones such as ubiquinone.
Therefore, a simple and rapid assay for ubiquinone in pharmaceutical preparation was developed based on the proposed chemiluminescence
reaction. The detection limit (blank + 3SD) of ubiquinone was 0.05 μM (9 ng/assay) with an analysis time of 30 s per sample.
The developed assay allowed the direct determination of ubiquinone in pharmaceutical preparation without any purification
procedure.
Figure Chemiluminescence generated through the redox cycle of quinone 相似文献
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鳙鱼心中电子载体泛醌化合物的研究 总被引:1,自引:1,他引:0
鳙鱼(Aristichthysnobilis)心脏提取物经硅胶柱色谱分离、制备薄层色谱纯化,得到二种泛醌化合物,用NMR、IR、MS、UV、HPLC、TLC等现代测试技术测定其化学结构为2,3-二甲氧基-5-甲基-6-10聚异戊二烯基-1,4-苯醌(Ⅰ)和一种未见报道的新泛醌酯——2,3-二甲氧基-5-甲基-6-甲酯基-八聚异戊二烯基-1,4-苯醌(Ⅱ)。 相似文献
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本选择泛醌作酶电极电子传统递体,将它和葡萄糖氧化酶、碳糊混和组成一种新的葡萄糖传感器,电极性能较不含泛醌的电极更优越,峰高ip与葡萄糖浓度在0.8×10^-5-1.6×10^-4mol/L范围内呈线性关系,电极灵敏度较高,干扰少,响应快,使用寿命长达三周。 相似文献
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H. Dronia U. Gruß G. Hägele T. Friedrich H. Weiss 《Journal of computer-aided molecular design》1996,10(2):100-106
Summary The structural and electronic properties of fluorinated 1-N-arylamino-1-arylmethanephosphonic acid esters were studied and related to the inhibitory effects on NADH:ubiquinone oxidoreductase (complex I). Electrostatic potential surfaces, dipole moments and molecular geometries were analysed. Based on the conformational analysis and the electronic parameters, a simple model for the active site of the fluorinated 1-N-arylamino-1-arylmethanephosphonic acid esters was developed, explaining the inhibitory power. The strongest inhibition effects were found for the 1-(N-4-trifluoromethoxyphenyl)-amino-1-phenylmethanephosphonic acid diethyl ester 1bab. 相似文献
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Wei MaHao Zhou Yi-Lun YingDa-Wei Li Guo-Rong ChenYi-Tao Long Hong-Yuan Chen 《Tetrahedron》2011,67(33):5990-6000
Quinones are a group of potent antineoplastic agents. Here we described effective and facile routes to synthesize a series of ubiquinone analogues (UQAs). These unique compounds have been investigated by electrochemistry and in situ UV-vis spectroelectrochemistry to explore their electron-transfer processes and radical properties in aprotic media. The structure-activities relationships of inhibiting cancer cell proliferation of UQAs were examined in murine melanoma B16F10 cells using a 72 h continuous exposure MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. Our results revealed that UQAs had improved antiproliferative activity and displayed better inhibitory effects than natural ubiquinone 10. The cytotoxic activities of UQAs were correlated to the semiubiquinone radicals, which were confirmed by in situ electron spin resonance (ESR). In the cytotoxicity test, 6-vinylubiquinone 5 and 6-(4′-fluorophenyl) ubiquinone 7 that possess half maximal inhibitory concentration value (IC50) of 6.1 μM and 6.2 μM. This would make them as valuable candidates for future pharmacological studies. 相似文献
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