Two new tricycloalternarenes from Hawaiian endophytic fungus Didymella sp. FT433

Two new compounds, tricycloalterenes M and N (1 and 2) and six known analogs were isolated from the cultured broth of Didymella sp. FT433. The structures of all the compounds were elucidated through the analysis of HRMS and NMR spectroscopic data. The absolute configurations (AC) of the new compounds were determined by CD. All compounds were tested against A2780 and cisplatin resistant A2780 (A2780CisR) cell lines, and pathogenic bacteria Staphylococcus aureus, Escherichia coli, Bacillus subtilis, and Pseudomonas aeruginosa, but none was active.