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Richard S. Belisle Christopher W. Via Tracey B. Schock Tracy A. Villareal Paul V. Zimba Kevin R. Beauchesne Peter D.R. Moeller Matthew J. Bertin 《Tetrahedron letters》2017,58(43):4066-4068
Mass spectrometry-guided isolation of the lipophilic extract of Trichodesmium bloom material led to the isolation and structure characterization of a new thiazole-containing di-chlorinated polyketide (1). The structure of 1 was deduced using 1D and 2D NMR analysis, high-resolution mass spectrometry analysis and complementary spectroscopic procedures. Trichothiazole A possesses interesting structural features, such as a terminal alkyne, two vinyl chlorides and a 2,4-disubstituted thiazole. Trichothiazole A showed moderate cytotoxicity to Neuro-2 A cells (EC50: 13.3 ± 1.1 μM). 相似文献
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