排序方式: 共有8条查询结果,搜索用时 31 毫秒
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David Schaffert Christina Troiber Eveline E. Salcher Thomas Frhlich Irene Martin Naresh Badgujar Christian Dohmen Daniel Edinger Raphaela Klger Gelja Maiwald Katarina Farkasova Silke Seeber Kerstin Jahn‐Hofmann Philipp Hadwiger Ernst Wagner 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2011,123(38):9149-9152
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Anthony J. Kirby Patrick Camilleri Jan B. F. N. Engberts Martin C. Feiters Roeland J. M. Nolte Olle Sderman Mark Bergsma Paul C. Bell Matthew L. Fielden Cristina L. García Rodríguez Philippe Gudat Andreas Kremer Caroline McGregor Christele Perrin Gaël Ronsin Marcel C. P. van Eijk 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2003,115(13):1486-1496
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Maruthibabu Paidikondala Vignesh Kumar Rangasami Ganesh N. Nawale Tommaso Casalini Giuseppe Perale Sandeep Kadekar Gaurav Mohanty Turkka Salminen Oommen P. Oommen Oommen P. Varghese 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2019,131(9):2841-2845
Circulating nucleic acids, such as short interfering RNA (siRNA), regulate many biological processes; however, the mechanism by which these molecules enter the cell is poorly understood. The role of extracellular‐matrix‐derived polymers in binding siRNAs and trafficking them across the plasma membrane is reported. Thermal melting, dynamic light scattering, scanning electron microscopy, and computational analysis indicate that hyaluronic acid can stabilize siRNA via hydrogen bonding and Van der Waals interactions. This stabilization facilitated HA size‐ and concentration‐dependent gene silencing in a CD44‐positive human osteosarcoma cell line (MG‐63) and in human mesenchymal stromal cells (hMSCs). This native HA‐based siRNA transfection represents the first report on an anionic, non‐viral delivery method that resulted in approximately 60 % gene knockdown in both cell types tested, which correlated with a reduction in translation levels. 相似文献
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