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1.
Excess tosyl chloride used in the tosylation of alcohols is quickly and easily removed by reacting it with cellulosic materials, e.g., filter paper, and filtering. 相似文献
2.
Preparation of some novel symmetrically tetrasubstituted metal-free phthalocyanine (6) and metallophthalocyanines (7-10) containing four 18-membered tetrathiadiaza macrocycles moieties on peripheral positions has been achieved by cyclotetramerization reaction of phthalonitrile derivative (5) in a multi-step reaction sequence. Metal-free phthalocyanine (6) was synthesized by microwave irradiation of 13,24-bis[(4-methylphenyl)sulfonyl]-6,7,14,15,23,24-hexahydro-13H,22H-tribenzo[b,h,n][1,4,10,13,7,16]tetrathiadiazacyclo-octadecine-18,19-dicarbonitrile (5) in 2-(dimethylamino)ethanol. The metallophthalocyanines (7-10) were prepared by the reaction of the phthalonitrile compound (5) with NiCl2, Zn(CH3COO)2, CoCl2, CuCl2 salts, respectively, by microwave irradiation in 2-(dimethylamino)ethanol for at 175 °C, 350 W. The new compounds were characterized by IR, 1H NMR, 13C NMR, UV-Vis, elemental analysis and MS spectra data. 相似文献
3.
A. Alcantara A. Ballesteros J. V. Sinisterra 《Applied biochemistry and biotechnology》1990,26(3):297-310
Improvement have been made in a simplified procedure we previously reported (J.Mol.Catal. (1986),38,227 for the activation
of tosyl chloride of supports possessing primary hydroxyl groups. The method is simple, can be completed in less than 90 min,
yields a broad range of activation degrees, and, since it involves no toxic reagents, may be used for preparing immobilized
enzymes to be utilized in food manufacturing and processing. The immobilization ofStophylococcal Nuclease has been carried out by this method. The insolubilized derivatives are more active than the native enzyme in the hydrolysis
of DNA. The thermal stability of nuclease derivatives is greater than that of the native enzyme. These derivatives remain
active at 50°C, and the native enzyme, 39°C. The insolubilized nuclease is more stable against organic solvents such as, dimethylsulfoxide
(DMSO) or tetrahydroduran (THF) than the native enzyme. 相似文献
4.
Zekeriya B?y?kl?o?lu 《Journal of organometallic chemistry》2008,693(3):505-509
The novel tetrasubstituted metal-free phthalocyanine (5) and metallophtalocyanines (6, 7 and 8) bearing four 19-membered dithiadiazadioxa macrocyclic moieties on peripheral positions have been synthesized by cyclotetramerization reaction of phthalonitrile derivative (4) in a multi-step reaction sequence. The new compounds were characterized by a combination of IR, 1H NMR, 13C NMR, UV-Vis, elemental analysis and MS spectral data. 相似文献
5.
Silica chloride has been found to be an efficient catalyst for facile tosylation of alcohols directly with p-toluenesulfonic acid in methylene chloride under reflux. The process is associated with selective tosylation of secondary alcohols over primary alcohols. 相似文献
6.
Verbalactone, a new macrocyclic dilactone was synthesized efficiently in a steroselective manner involving a Barbier-Grignard reaction, a Sharpless asymmetric dihydroxylation, monotosylation, epoxidation, ring opening of the epoxide, hydrolysis and lactonization. A δ-lactone, (+)-(3R,5R)-3-hydroxy-5-decanolide was also formed along with the dimeric lactone. 相似文献
7.
《Journal of carbohydrate chemistry》2013,32(6-7):417-434
Abstract Methyl 3‐azido‐2,3‐dideoxy‐α/β‐D‐arabino‐ and ‐α/β‐D‐ribo‐hexopyranosides were transformed into 6‐iodo analogues via p‐tolylsulfonyl compounds. Elimination of hydrogen iodide from 6‐iodo glycosides provided methyl 4‐O‐acetyl‐3‐azido‐2,3,6‐trideoxy‐α‐ and ‐β‐D‐threo‐hex‐5‐eno‐pyranosides or 3‐azido‐4‐O‐p‐tolylsulfonyl‐2,3,6‐trideoxy‐α‐D‐threo‐ and ‐β‐D‐erythro‐hex‐5‐eno‐pyranosides. Ferrier's carbocyclization of 4‐O‐acetyl‐3‐azido‐2,3,6‐trideoxy‐α‐ and ‐β‐D‐threo‐hex‐5‐eno‐pyranosides gave (2S,3R,5R)‐2‐acetoxy‐3‐azido‐5‐hydroxycyclohexanone, which was converted into oxime. The 2‐OAc group in oxime was substituted by azide ion to yield (2R,3R,5R)‐2,3‐diazido‐5‐hydroxycyclohexanone oxime. The configuration and conformation of all products are widely discussed on the basis of the 1H and 13C NMR. 相似文献
8.
The novel tetrasubstituted metal-free phthalocyanine (6) and metallophthalocyanines (7, 8) bearing four 14-membered tetraaza macrocycles moieties on peripheral positions have been synthesized by cyclotetramerization reaction of phthalonitrile derivative (5) in a multi-step reaction sequence. The new compounds were characterized by a combination of IR, 1H NMR, 13C NMR, UV-vis, elemental analysis and MS spectral data. 相似文献
9.
Palakuri RameshH.M. Meshram 《Tetrahedron letters》2012,53(31):4008-4011
An efficient synthesis of (−)-anamarine is described using d(+)-mannitol and (R)-epichlorohydrin. The synthesis is achieved starting from easily accessible d(+)-mannitol using a selective benzoylation, regioselective epoxide ring opening, a selective acetonide deprotection, tosylation and cross metathesis reaction. 相似文献
10.
Erika?Kozma Ioan?Cristea Norbert?MüllerEmail author 《Monatshefte für Chemie / Chemical Monthly》2004,135(1):35-40
Summary. Pure (1S,2R,4S)-1,2-epoxy-p-menthan-4-ol and (1R,2S,4R)-1,2-epoxy-p-menthan-4-ol (trans-epoxides of (4S)-terpinen-4-ol and (4R)-terpinen-4-ol) were prepared and certain reactions of these compounds with nucleophilic reagents were studied. It was shown that the Fürst-Plattner rule regarding the trans-diaxial opening of cyclohexene epoxides predicts the predominant products in all cases studied. 相似文献