排序方式: 共有23条查询结果,搜索用时 859 毫秒
1.
Two new neolignans, syripinnalignins A and B ( 1 and 2 , resp.), were isolated from the 95% EtOH extract of the stem of Syringa pinnatifolia Hemsl . var. alashanensis. The structures of 1 and 2 were elucidated by spectroscopic methods, including UV, IR, HR‐ESI‐MS, and extensive 1D‐ and 2D‐NMR techniques. 相似文献
2.
Xue Song Feng Yang Qua Zhao Hua Wuc Lei Xua Dong Song Zhanga Hui Yuan Gaoa Li Jun Wu a School of Traditional Chinese Medicines Shenyang Pharmaceutical University Shenyang China b School of Pharmaceutical Sciences China Medical University Shenyang China c Pharmacy Department Mudanjiang Medical University Mudanjiang China 《中国化学快报》2009,20(6)
Chemical investigation of Syringa velutina Kom. led to the isolation of two new secoiridoid glucosides. Their structures were identified as 6'-0-(6, 7-dihyrofoliamenthoyl)-8-epi-kingisidic acid (syrveoside A, 1) and 6'-O-menthiafoloyl-8-epi-kingisidic acid (syrveoside B, 2) on the basis of chemical and physicochemical evidence. 相似文献
3.
A new 6,9-cyclotetrahydrofuranlignan, 3,3′-dimethoxy-4,4′-dihydroxy-8β,9β,8′α-6,9-cyclotetrahydrofuranlignan, was isolated from the stem of Syringa pinnatifolia Hems1.var. alashanensis MA. et S. Q. ZHOU. Its structures were elucidated on the basis of spectroscopic methods including UV, IR, ESI-MS, 1D NMR and 2D NMR. 相似文献
4.
Ahmed A. Al-Karmalawy Mai M. Farid Ahmed Mostafa Alia Y. Ragheb Sara H. Mahmoud Mahmoud Shehata Noura M. Abo Shama Mohamed GabAllah Gomaa Mostafa-Hedeab Mona M. Marzouk 《Molecules (Basel, Switzerland)》2021,26(21)
Flavonoids are important secondary plant metabolites that have been studied for a long time for their therapeutic potential in inflammatory diseases because of their cytokine-modulatory effects. Five flavonoid aglycones were isolated and identified from the hydrolyzed aqueous methanol extracts of Anastatica hierochuntica L., Citrus reticulata Blanco, and Kickxia aegyptiaca (L.) Nabelek. They were identified as taxifolin (1), pectolinarigenin (2), tangeretin (3), gardenin B (4), and hispidulin (5). These structures were elucidated based on chromatographic and spectral analysis. In this study, molecular docking studies were carried out for the isolated and identified compounds against SARS-CoV-2 main protease (Mpro) compared to the co-crystallized inhibitor of SARS-CoV-2 Mpro (α-ketoamide inhibitor (KI), IC50 = 66.72 µg/mL) as a reference standard. Moreover, in vitro screening against SARS-CoV-2 was evaluated. Compounds 2 and 3 showed the highest virus inhibition with IC50 12.4 and 2.5 µg/mL, respectively. Our findings recommend further advanced in vitro and in vivo studies of the examined isolated flavonoids, especially pectolinarigenin (2), tangeretin (3), and gardenin B (4), either alone or in combination with each other to identify a promising lead to target SARS-CoV-2 effectively. This is the first report of the activity of these compounds against SARS-CoV-2. 相似文献
5.
Phenylpropanoids from Medicinal Plants: Distribution, Classification, Structural Analysis, and Biological Activity 总被引:3,自引:0,他引:3
V. A. Kurkin 《Chemistry of Natural Compounds》2003,39(2):123-153
The literature and our own research results on phenylpropanoids from medicinal plants were reviewed and systematized. Data were presented for the distribution of phenylpropanoids. Their classification was proposed. The biological structure-activity relationships for compounds found in roseroot (Rhodiola rosea), thorny eleutherococcus (Eleutherococus senticosus), common lilac (Syringa vulgaris), purple echinacea (Echinacea purpurea), medicinal melissa (Melissa officinalis), variegated milk-thistle (Silybum marianum), and others were discussed. 相似文献
6.
Guozhu Su Ruifeng Bai Xuelong Yu Yuan Cao Xu Yin Pengfei Tu 《Natural product research》2016,30(19):2149-2153
One new norlignan, namely noralashinol A (1), one known analogue (2), together with seven known lignans (3–9) were isolated from the stem barks of Syringa pinnatifolia. Their structures were elucidated extensively by spectroscopic methods, including mass spectrometry and 1D and 2D NMR spectroscopies. Compound 8 significantly inhibited NO production in LPS-induced BV-2 murine microglia cells with its IC50 value of 20.7 μM, compared to a positive control quercetin with its IC50 value of 15.3 μM. 相似文献
7.
Ga-Ram Kim Eun-Nam Kim Kyoung Jin Park Ki Hyun Kim Gil-Saeng Jeong 《Molecules (Basel, Switzerland)》2021,26(6)
Osteoblasts and osteoclasts play a pivotal role in maintaining bone homeostasis, of which excessive bone resorption by osteoclasts can cause osteoporosis and various bone diseases. However, current osteoporosis treatments have many side effects, and research on new treatments that can replace these treatments is ongoing. Therefore, in this study, the roles of ligustroside (LGS) and oleoside dimethylester (ODE), a natural product-derived compound isolated from Syringa oblata subsp. dilatata as a novel, natural product-derived osteoporosis treatments were investigated. In the results of this study, LGS and ODE inhibited the differentiation of receptor activator of nuclear factor kappa-Β ligand (RANKL)-induced RAW264.7 cells into osteoclasts without cytotoxicity, and down-regulated the activity of TRAP, a specific biomarker of osteoclasts. In addition, it inhibited bone resorption and actin ring formation, which are important functions and features of osteoclasts. Also, the effects of LGS and ODE on the mitogen-activated protein kinase (MAPK) and nuclear factor kappa-light-chain-enhancer of activated B (NF-κB) and phosphoinositide 3-kinases (PI3K)/ protein kinase B (Akt)/mechanistic target of rapamycin (mTOR) signaling pathways that play important roles in osteoclast differentiation were evaluated. In the results, LGS and ODE downregulated the phosphorylation of RANKL-induced MAPK and PI3K/Akt/mTOR proteins in a concentration-dependent manner, translocation of NF-κB into the nucleus was inhibited. As a result, the compounds LGS and ODE isolated from S. oblate subsp. dilatata effectively regulated the differentiation of RANKL-induced osteoclasts and inhibited the phosphorylation of signaling pathways that play a pivotal role in osteoclast differentiation. Therefore, these results suggest the possibility of LGS and ODE as new natural product treatments for bone diseases caused by excessive osteoclasts. 相似文献
8.
Erzsébet Varga Csenge Barabás Anita Tóth Imre Boldizsár Béla Noszál 《Natural product research》2019,33(11):1664-1669
Metabolite profile, antioxidant and antinociceptive activities of Syringa vulgaris bark and leaf methanolic extracts were investigated. By means of HPLC-DAD-ESI-TOF and HPLC-DAD-ESI-MS/MS, a total of 33 phenolics were identified, including 15 secoiridoids, 6 phenylpropanoids, 3 flavonoids, 3 lignans and 6 low molecular weight phenols. Validated quantitative analysis show that syringin (2.52%) and rutin (1.13%) are the main phenolic compounds in bark and leaf, respectively. Notable radical scavenging and antinociceptive activities of the bark and leaf extracts were confirmed by in vitro DPPH● and ABTS●+ assays and by in vivo hot-plate method in mice, respectively. Our results could lay the scientific basic of future clinical perspectives of lilac bark and leaf. 相似文献
9.
10.
移动子窗口搜索法在紫丁香挥发油气相色谱-质谱分析中的应用 总被引:1,自引:0,他引:1
基于气相色谱-质谱仪产生的二维数据,采用移动子窗口搜索法,以纯组分峰为标准对同一样品在不同色谱柱上或不同样品在相同色谱柱上所获得的总离子流图的一定保留时间范围内搜索,可以得到目标化合物的流出区域,取其中点作为保留时间,从而计算各化合物在不同极性色谱柱上的程序升温保留指数。采用GC-MS与色谱保留指数相结合的方法,分别在HP-5MS和DB-35MS柱上,于80℃~290℃(4℃/min)的升温程序下,对黑龙江产紫丁香花蕾与花挥发油的分析结果表明,辅以化学计量学方法和双柱色谱保留指数定性比单用GC-MS定性结果更加快速可靠。 相似文献