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1.
Yuta Yamamoto Shogo Nakano Fumio Seki Yasuteru Shigeta Sohei Ito Hiroaki Tokiwa Makoto Takeda 《Molecules (Basel, Switzerland)》2021,26(5)
Infection of hosts by morbilliviruses is facilitated by the interaction between viral hemagglutinin (H-protein) and the signaling lymphocytic activation molecule (SLAM). Recently, the functional importance of the n-terminal region of human SLAM as a measles virus receptor was demonstrated. However, the functional roles of this region in the infection process by other morbilliviruses and host range determination remain unknown, partly because this region is highly flexible, which has hampered accurate structure determination of this region by X-ray crystallography. In this study, we analyzed the interaction between the H-protein from canine distemper virus (CDV-H) and SLAMs by a computational chemistry approach. Molecular dynamics simulations and fragment molecular orbital analysis demonstrated that the unique His28 in the N-terminal region of SLAM from Macaca is a key determinant that enables the formation of a stable interaction with CDV-H, providing a basis for CDV infection in Macaca. The computational chemistry approach presented should enable the determination of molecular interactions involving regions of proteins that are difficult to predict from crystal structures because of their high flexibility. 相似文献
2.
An Improved Gradient Projection-based Decomposition Technique for Support Vector Machines 总被引:2,自引:0,他引:2
Luca Zanni 《Computational Management Science》2006,3(2):131-145
In this paper we propose some improvements to a recent decomposition technique for the large quadratic program arising in
training support vector machines. As standard decomposition approaches, the technique we consider is based on the idea to
optimize, at each iteration, a subset of the variables through the solution of a quadratic programming subproblem. The innovative
features of this approach consist in using a very effective gradient projection method for the inner subproblems and a special
rule for selecting the variables to be optimized at each step. These features allow to obtain promising performance by decomposing
the problem into few large subproblems instead of many small subproblems as usually done by other decomposition schemes. We
improve this technique by introducing a new inner solver and a simple strategy for reducing the computational cost of each
iteration. We evaluate the effectiveness of these improvements by solving large-scale benchmark problems and by comparison
with a widely used decomposition package. 相似文献
3.
A. V. Kel’manov L. V. Mikhailova 《Computational Mathematics and Mathematical Physics》2006,46(1):165-181
The problem of joint a posteriori detection of reference fragments in a quasi-periodic sequence and its partition into segments containing series of recurring fragments from the reference tuple is solved. It is assumed that (i) an ordered reference tuple of sequences to be detected is given, (ii) the number of desired fragments is known, (iii) the index of the sequence term corresponding to the beginning of a fragment is a deterministic (not random) value, and (iv) a sequence distorted by an additive uncorrelated Gaussian noise is available for observation. It is established that the problem consists in testing a set of hypotheses about the mean of a random Gaussian vector. The cardinality of the set grows exponentially as the vector dimension (i.e., the sequence length) increases. An efficient a posteriori algorithm producing a maximum-likelihood optimal solution to the problem is substantiated. Time and space complexity bounds related to the parameters of the problem are derived. The results of numerical simulation are presented. 相似文献
4.
Huseyin Ince 《Computational Management Science》2006,3(2):161-174
The nature of the financial time series is complex, continuous interchange of stochastic and deterministic regimes. Therefore,
it is difficult to forecast with parametric techniques. Instead of parametric models, we propose three techniques and compare
with each other. Neural networks and support vector regression (SVR) are two universally approximators. They are data-driven
non parametric models. ARCH/GARCH models are also investigated. Our assumption is that the future value of Istanbul Stock
Exchange 100 index daily return depends on the financial indicators although there is no known parametric model to explain
this relationship. This relationship comes from the technical analysis. Comparison shows that the multi layer perceptron networks
overperform the SVR and time series model (GARCH). 相似文献
5.
Satya Prakash 《Pramana》1989,33(1):109-131
This article summarizes the recent radiochemical investigations on mass, charge kinetic energy and fragment angular distributions
in low energy fission of actinides. 相似文献
6.
梅家骝 《高校应用数学学报(A辑)》1989,4(4):541-549
本文讨论了笔者在[1]中提出的伪凸集,拟凸集的支撑函数与障碍锥的性质,并通过这些性质得出了二个闭性准则。 相似文献
7.
本文我们利用一个可微函数给出了一对高阶对称规划问题 ,其中目标函数包含了Rn 中一紧凸集的支撑函数 .在引入高阶F 凸性 (F 伪凸性 ,F 拟凸性 )后 ,证明了高阶弱、高阶强及高阶逆对称对偶性质 . 相似文献
8.
In this paper we construct the linear support vector machine (SVM) based on the nonlinear rescaling (NR) methodology (see
[Polyak in Math Program 54:177–222, 1992; Polyak in Math Program Ser A 92:197–235, 2002; Polyak and Teboulle in Math Program
76:265–284, 1997] and references therein). The formulation of the linear SVM based on the NR method leads to an algorithm
which reduces the number of support vectors without compromising the classification performance compared to the linear soft-margin
SVM formulation. The NR algorithm computes both the primal and the dual approximation at each step. The dual variables associated
with the given data-set provide important information about each data point and play the key role in selecting the set of
support vectors. Experimental results on ten benchmark classification problems show that the NR formulation is feasible. The
quality of discrimination, in most instances, is comparable to the linear soft-margin SVM while the number of support vectors
in several instances were substantially reduced. 相似文献
9.
Johan van Benthem 《Logica Universalis》2007,1(1):125-138
We prove new Lindstr?m theorems for the basic modal propositional language, and for some related fragments of first-order
logic. We find difficulties with such results for modal languages without a finite-depth property, high-lighting the difference
between abstract model theory for fragments and for extensions of first-order logic. In addition we discuss new connections
with interpolation properties, and the modal invariance theorem.
Mathematics Subject Classification (2000): Primary 03B45; Secondary 03C95 相似文献
10.
Wanpracha Art Chaovalitwongse Oleg A. Prokopyev Panos M. Pardalos 《Annals of Operations Research》2006,148(1):227-250
Epilepsy is among the most common brain disorders. Approximately 25–30% of epilepsy patients remain unresponsive to anti-epileptic
drug treatment, which is the standard therapy for epilepsy. In this study, we apply optimization-based data mining techniques
to classify the brain's normal and epilepsy activity using intracranial electroencephalogram (EEG), which is a tool for evaluating
the physiological state of the brain. A statistical cross validation and support vector machines were implemented to classify
the brain's normal and abnormal activities. The results of this study indicate that it may be possible to design and develop
efficient seizure warning algorithms for diagnostic and therapeutic purposes.
Research was partially supported by the Rutgers Research Council grant-202018, the NSF grants DBI-980821, CCF-0546574, IIS-0611998,
and NIH grant R01-NS-39687-01A1. 相似文献