排序方式: 共有6条查询结果,搜索用时 382 毫秒
1
1.
2.
3.
4.
5.
6.
James R. Walker Jeffrey E. Merit Rhiannon Thomas‐Tran Doris T. Y. Tang J. DuBois 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2019,131(6):1703-1707
The bis‐guanidinium toxins are a collection of natural products that display nanomolar potency against select isoforms of eukaryotic voltage‐gated Na+ ion channels. We describe a synthetic strategy that enables access to four of these poisons, namely 11‐saxitoxinethanoic acid, C13‐acetoxy saxitoxin, decarbamoyl saxitoxin, and saxitoxin. Highlights of this work include an unusual Mislow–Evans rearrangement and a late‐stage Stille ketene acetal coupling. The IC50 value of 11‐saxitoxinethanoic acid was measured against rat NaV1.4, and found to be 17.0 nm , similar to those of the sulfated toxins gonyautoxin II and III. 相似文献
1