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Dr. Yihui Xie Danni Luo Jesse A. Wiener Dr. Alexander B. Koval Dr. Conrad T. Pfeiffer Prof. Christian E. Schafmeister 《Angewandte Chemie (International ed. in English)》2023,62(27):e202302809
Here, we report a new class of peptidomimetic macrocycles with well-defined three-dimensional structures and low conformational flexibility. They are assembled from fused-ring spiro-ladder oligomers (spiroligomers) by modular solid-phase synthesis. Two-dimensional nuclear magnetic resonance confirms their shape persistency. Triangular macrocycles of tunable sizes assemble into membranes with atomically precise pores, which exhibit size and shape-dependent molecular sieving towards a series of structurally similar compounds. The exceptional structural diversity and stability of spiroligomer-based macrocycles will be explored for more applications. 相似文献
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