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Chao Jie WANG Jian Hong WANG Ying GAN Zhi Yong CHEN Gang Jun DU Jin ZHAO 《中国化学快报》2006,17(10):1301-1304
Chemotherapy is one of the most important treatments of cancer, however, clinical use of conventional anticancer drugs is often limited by their side effects such as toxicity for normal tissues and multidrug resistance of tumor cells1, 2. Because of the s… 相似文献
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WANG Jian-hong WANG Chao-jie GAN Ying DU Gang-jun ZHAO Jin 《高等学校化学研究》2007,23(4):417-420
To further explore the biological activities of solanesylamine derivatives,several novel solanesylpiperazinotriamines and their amides were designed and synthesized,the chemical structures of target compounds were confirmed by IR,1H NMR,MS,and element analysis.The in vitro antitumor activities of the synthetic compounds were assessed by MTT test on L1210 and CHO cells.The preliminary results showed that at low micromolar concentrations these compounds exhibit obvious toxicity against tumor cells,and the synergistic effect on clinical antitumor agent indicated that at noncytotoxic concentrations,they also evidently enhance the curative effect of vincristine(VCR).The synergistic effects of compounds 4a,4c,and 9 were even superior to that of reference compound N,N'-bis(3,4-dimethoxybenzyl)-N-solanesyl-ethylenediamine(SDB). 相似文献
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