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To investigate the bioactive constituents of the inflorescences of Scabiosa comosa and S. tschilliensis, which are used traditionally for liver diseases, we tested the antioxidant activity using 2,2′-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azinobis-(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS), ferric reducing antioxidant potential (FRAP), and DPPH-ultra high performance liquid chromatography-mass spectrometer (UPLC-MS) assay. In addition, cell-based anti-HCV activity of the major compounds were evaluated. The plant extracts showed strong antioxidant activity. For the first time, 3,4-dicaffeoylquinic acid (DCQA), 3,5-DCQA and 4,5-DCQA were identified from genus Scabiosa. A UPLC-MS method in multiple reaction monitoring (MRM) mode was established to quantify 18 constituents in the inflorescences of Scabiosa. The 3,5-DCQA, chlorogenic acid and some glycosides of luteolin or apigenin were found to be the most abundant constituents. Chlorogenic acid and 3,5-DCQA showed excellent radical scavenging activity and demonstrated anti-HCV activity. These findings provided scientific evidences for the clinic use of this herbal medicine for liver diseases. 相似文献
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Constituents of the essential oil of Scabiosa flavida from Iran 总被引:1,自引:0,他引:1
The composition of the essential oil of the aerial parts of Scabiosa flavida was investigated by GC and GC-MS. Forty-three components representing 94.2% of the essential oil were characterized. The
main components of the oil were tricosane (15.5%), rosifoliol (15.3%), (E)-caryophyllene (10.7%), and α-humulene (7.9%).
Published in Khimiya Prirodnykh Soedinenii, No. 5, pp. 426–427, September–October, 2006. 相似文献
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