COMPOSITION OF THE ESSENTIAL OIL OF Haplophyllum myrtifolium

The chemical composition of the essential oil ofHaplophyllum myrtifoliumBoiss., endemic to Turkey, was examined by GC/MS. Ninety-seven compounds were characterized with linalool (12.8%), -caryophyllene (10.3 %), and methyleugenol (5.9 %) as the main constituents.     

Cytotoxic Constituents from the Stem Bark of Zanthoxylum Pistaciiflorum

Two new esters, methyl 4‐(prenyloxy)dihydrocinnamate and methyl 4‐(geranyloxy)dihydrocinnamate, together with fourteen known compounds have been isolated from the stem bark of Zanthoxylum pistaciiflorum. The structures of two new compounds were determined through spectral analyses. Among the isolates, four compounds exhibited effective cytotoxicities against P‐388 and HT‐29 cell lines in vitro.     

Constituents of Leaves of Tetradium Glabrifolium

Twenty-nine compounds including three alkaloids, live triterpenoids, five coumarins, seven benzenoids, two tannins, five flavonoids, one sugar and one nucleoside are isolated from leaves of Tetradium glabrifolium. Their structures are characterized on comparison of spectral data with literature values.     

Constituents of Flowers of Murraya Paniculata

Three new coumarins, yuehgesin-A (1), -B (2) and -C (3) and 22 compounds—murracarpin (4), mupanidin (5), isomeranzin (6), murralongin (7), scopoletin (10), 7-methoxy-8-(l′-ethoxy-2′-hydroxy-3′-methyl-3′-butenyl)coumarin (11), umbelliferone (12), paniculatin (13), braylin (14), auraptenol (15), meranzin hydrate (16), minumicrolin (17), scopolin (18), caffeine (19), 3,3′,4′,5,5′,6,7-heptamethoxyflavone (20), 4-hy-droxybenzaldebyde (21), p-hydroxybenzoic acid (22), cis- and trans-ferulic acid (23), cis- and transmethyl ferulate (24) and trans-ethylferulate (25)—were isolated and characterized from fresh flowers of Murraya paniculata collected in Taiwan. Their structures were elucidated by spectral methods. The chemotaxonomy of Murraya paniculata is, discussed.     

Chalepin and Chalepensin: Occurrence,Biosynthesis and Therapeutic Potential

Dihydrofuranocoumarin, chalepin (1) and furanocoumarin, chalepensin (2) are 3-prenylated bioactive coumarins, first isolated from the well-known medicinal plant Ruta chalepensis L. (Fam: Rutaceae) but also distributed in various species of the genera Boenminghausenia, Clausena and Ruta. The distribution of these compounds appears to be restricted to the plants of the family Rutaceae. To date, there have been a considerable number of bioactivity studies performed on coumarins 1 and 2, which include their anticancer, antidiabetic, antifertility, antimicrobial, antiplatelet aggregation, antiprotozoal, antiviral and calcium antagonistic properties. This review article presents a critical appraisal of publications on bioactivity of these 3-prenylated coumarins in the light of their feasibility as novel therapeutic agents and investigate their natural distribution in the plant kingdom, as well as a plausible biosynthetic route.     

Complete NMR assignment of 3, 4‐seco‐lup‐20(29)‐en‐3‐oic acid from Decatropis bicolor

Complete ¹H and ¹³C NMR chemical shift assignments for 3,4‐seco‐lup‐20(29)‐en‐3‐oic acid ( 1 ) have been established by means of two‐dimensional COSY, HSQC, HMBC and NOESY spectroscopic experiments as well as by analysis of MS data. Compound 1 was isolated from Decatropis bicolor (Zucc.) Radlk. (Rutaceae) in addition to six coumarins and one alkaloid of known structure. Copyright © 2012 John Wiley & Sons, Ltd.     

Two acridones and two coumarins from the roots of Paramignya trimera

Two acridones, paratrimerins C (1) and D (2), and two coumarins, paratrimerins E (3) and F (4), were isolated from the CHCl₃ and EtOAc extracts of Paramignya trimera (Rutaceae), together with twelve known compounds (5–16). Their structures were elucidated on the basis of spectroscopic data. All isolated compounds possessed significant α-glucosidase inhibitory activity in a concentration-dependent manner, and showed more potent inhibitory activity, with IC₅₀ values ranging from 14.6 to 112.2 μM, than the positive control acarbose (IC₅₀, 214.5 μM). The biosynthesis of the isolated coumarins and acridones was proposed.     

A new flavone C-glucoside from Glycosmis arborea (Rutaceae)

<正>A new C-glycosyl flavone 7,4'-dihydroxy-5-methoxyflavone-6-C-β-D-glucopyranoside 1 has been isolated and characterized form ethanolic extract of leaves part of Glycosmis arborea.The structure of compound was verified by means of high field 1D and 2D NMR(DEFT,COSY,DQF-HSQC,HMBC) and HRMS spectral analysis,respectively.     

Three New Coumarins from Micromelum integerrimum

Micromelum integerrimum (Rutaceae) is a shrub growing in Yunnan Province. Leaves and barks of this plant have been used for the treatment of dysentery, and arthritis1. Previous researches revealed that this plant contained coumarins2-8. Micromelin, the main chemical constituent of this plant, showed significant inhibition against leukaemia P-388 cell line (T/C 149% at 10 mg/kg) but was inactive in lower doses, and also showed significant activity (T/C 228% at 1.25 mg/kg) against Lewis lung…     

Chemical Constituents from the Root Bark of Formosan Zanthoxylum Ailanthoides

Two new N‐isobutylamides, hydroxy lanyuamide I ( 1 ) and hydroxy lanyuamide II ( 2 ), together with one hundred and ten known compounds, have been isolated from the root bark of Formosan Zanthoxylum ailanthoides. These known compounds include twenty coumarins, twenty‐one benzo[c]phenanthridines, ten quinoline derivatives, one aporphine, one purine, seven amides, twelve benzenoids, one lactone, four flavonoids, nine lignans, eight steroids, two chlorophylls, eleven terpenoids and three other compounds, which were determined by means of spectral analyses.