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1.
V. Anuradha 《Tetrahedron letters》2006,47(28):4933-4935
Highly regiospecific mononitration of phenols and substituted phenols is accomplished employing a metal nitrate and a catalytic amount of p-toluenesulfonic acid in acetone. An exclusive ortho-selectivity was observed with excellent yields. A variety of metal nitrates were used to obtain o-nitrophenols exclusively in good to excellent yields. The use of p-toluenesulfonic acid is key for the selectivity observed. 相似文献
2.
Addition reaction of two geometrical isomers of 1-chlorovinyl p-tolyl sulfoxides, derived from unsymmetrical ketones and chloromethyl p-tolyl sulfoxide, with lithium enolate of tert-butyl acetate gave single isomers of the adduct, respectively. Treatment of each diastereomer with i-PrMgCl resulted in the formation of magnesium carbenoids. Highly regiospecific 1,3-CH insertion reaction was found to take place from the magnesium carbenoids to afford cyclopropanes in high yields. Stereochemistry of the adducts, reaction mechanism, and origin of the regiospecificity are discussed. 相似文献
3.
Pintu K. Kundu 《Tetrahedron》2010,66(44):8562-8568
The β-aryl-β-silyl and β,β-disilyl propionates have been synthesized from cinnamates and β-silyl acrylates by a regiospecific reductive C-silylation using Mg/silyl chloride/DMF system at room temperature. These reductive C-silylation conditions have also been applied to δ-aryl substituted dienoates wherein silylation took place at the δ-position leading to the synthesis of single regioisomeric allylsilanes with very high stereoselectivity. 相似文献
4.
Thivisha Rajagopal 《Tetrahedron》2010,66(45):8739-8744
E-β-Chloro-α-iodo-α,β-unsaturated esters were converted to single isomer trisubstituted olefins bearing alkyl substituents by using and alkyl-Suzuki cross coupling. The process was highly selective, and the products in all cases were isolated as single isomers. Mechanistic investigations indicated that this process transfers a hydrogen from water to the α-position of the substrate, and then an alkyl group is introduced to the β-position of the intermediate template while replacing a chloride. 相似文献
5.
Madhav S. Mane Ravi S. Balaskar Sandip N. Gavade Pramod N. Pabrekar Murlidhar S. Shingare Dhananjay V. Mane 《中国化学快报》2011,22(9):1039-1042
The regiospecific oxidation of alkyl group of both sterically hindered and unhindered aromatic amine to corresponding carbonyl compound was done in aq. medium by using DDQ. The optimized reaction protocol was found to be most simple, high yielding and novel method for oxidation of alkyl group of aromatic amine in to its carbonyl compound. 相似文献
6.
Vinod K. Ahluwalia Daljeet Singh Rishi P. Singh 《Monatshefte für Chemie / Chemical Monthly》1984,115(8-9):1059-1064
Condensation of hydroxybenzaldehydes viz., 2,3,4-trihydroxy-, 2,4-dihydroxy-, 2,4-dihydroxy-6-methyl-, and 2,4-dihydroxy-3-iodo-6-methylbenzaldehydes with buta-1,3-diene in the presence of orthophosphoric acid yields crotylbenzaldehydes in one step. The latter compounds on cyclisation afford the corresponding 2-methylformylchromans.
Eine einfache Synthese von Crotylbenzaldehyden und 2-Methylformyl-chromanen
Zusammenfassung Die Kondensation von Hydroxybenzaldehyden (2,3,4-Trihydroxy-, 2,4-Dihydroxy-, 2,4-Dihydroxy-6-methyl-, und 2,4-Dihydroxy-3-jod-6-methyl-benzaldehyd) mit Buta-1,3-dien in Gegenwart von Orthophosphorsäure ergibt in einer Stufe Crotylbenzaldehyde. Diese lassen sich durch Cyclisierung zu den entsprechenden 2-Methylformylchromanen umsetzen.相似文献
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8.
《Arabian Journal of Chemistry》2019,12(5):680-693
A general five-step synthesis of a short library of benzo[7,8]indolizinoquinolinine analogues of the topoisomerase-1 (topo-1) poison rosettacin and 22-hydroxyacuminatine alkaloids from DMAD and ortho-ketoanilines is reported. This consists on successively, the tandem aza-Michael addition/cyclodehydration, the hydrolysis of the resulting diesters into corresponding o-dicarboxylic acids, and the tandem intermolecular amidation/cyclodehydration into N-substituted imides. The regioselective reduction of one imide carbonyl into corresponding α-hydroxy lactams promoted by a Lewis acid Mg(ClO4)2 was followed ultimately with TFA-promoted π-cationic cyclization via stable N-acyliminiums species as an important key step. 相似文献
9.
Makam S Raghavendra 《Tetrahedron letters》2004,45(32):6129-6132
A traceless and regiospecific solid-phase synthesis of substituted 1,2,3-triazoles is developed using polystyrene-sulfonyl hydrazide resin. The chemistry is applicable to combinatorial library synthesis. 相似文献
10.
The cross-coupling reaction of (Z) 1-bromo-1-fluoroalkenes catalyzed by PdCl2(PPh3)2-2PPh3 (3%) and CsF in Tetrahydrofuran (THF) in presence of bis(pinacolato)diboron led to (1E,3E) 2,3-difluoro-1,4-disubstituted-buta-1,3-dienes in high yields. 相似文献