排序方式: 共有1条查询结果,搜索用时 0 毫秒
1
1.
Christopher M. Timperley Matthew J. Waters Jackie A. Greenall 《Journal of fluorine chemistry》2006,127(2):249-256
Reactions of perfluoroisobutene (PFIB), perfluoropropene (PFP) and chlorotrifluoroethene (CTFE) with benzenethiol and 2-methoxybenzenethiol in acetonitrile, with potassium carbonate as base, were compared. PFIB reacted with benzenethiol to give ketene thioacetal (CF3)2CC(SAr)2 and with 2-methoxybenzenethiol to give mono- and bis-vinyl species (CF3)2CCFSAr and (CF3)2CC(SAr)2. PFP reacted with both thiols to give the addition product CF3CFHCF2SAr and vinyl isomers CF3CFCFSAr (6:1 E/Z ratio). CTFE reacted with several methoxy-substituted arylthiols to give addition products of structure CFClHCF2SAr. The arylthiols used throughout the study imitate biological thiols. Inhalation toxicities of the fluoroalkenes decrease in the order PFIB > PFP > CTFE and correlate with their reactivities towards the model thiols, supporting the current view that their toxicity relates to their ability to react with biological thiols. 相似文献
1