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Kerry J. GoodworthAnne-Cécile Hervé Evangelos StavropoulosGwénaelle Hervé Isabel Casades Alison M. HillGordon G. Weingarten Ricardo E. TasconM. Joseph Colston Helen C. Hailes 《Tetrahedron》2011,67(2):373-382
A series of large-ringed calix[6,7,8]arene analogues have been synthesised and their affect against Mycobacterium tuberculosis in vivo established. In general, when p-phenylcalixarenes and tert-butylcalixarenes were not functionalised at the lower rim, low biological activities were observed. However on going from partially to fully lower rim pegylated calixarenes the anti-mycobacterial properties improved. The addition of cyanopropoxy groups at the lower rim gave rise to low activities, whereas the addition of acetate moieties interestingly had pro-TB effects. Two upper rim sulfonated calixarenes showed promising properties. In the course of this work, a high yielding procedure to synthesise p-phenylcalix[7]arene was also established. 相似文献
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