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1.
An enantioselective Michael addition of malonate to nitroalkenes is efficiently catalyzed by low loading demethylquinine salts in water; the yield range from 49% to 93% and the ee up to 90%.  相似文献   
2.
Summary Optically activeMichael adducts were synthesized by addition of 1,3-dicarbonyl compounds to conjugated nitroalkenes. Good chemical yields were obtained for nitroalkenes stabilized by an aromatic substituent without any further substituents at the double bond. Acetylacetone and methyl-2,3-dihydro-1-oxo-1H-indene-2-carboxylate were used asMichael donors and four cinchona alkaloids as chiral base catalysts. Enantiomeric excess determinations were performed by1H NMR spectroscopy in the presence of thePirkle alcohol and by HPLC on chiral stationary phases. A correlation between the relative configuration of the prevailing isomer of theMichael adduct and the catalysts was established.
Asymmetrische Katalyse, 103. Mitt.: EnantioselektiveMichael-Addition von 1,3-Dicarbonylverbindungen an konjugierte Nitroalkene
Zusammenfassung Optisch aktiveMichael-Addukte werden durch die Addition von 1,3-Dicarbonylverbindungen an konjugierte Nitroalkene synthetisiert. Gute chemische Ausbeuten werden für durch aromatische Substituenten stabilisierte Nitroalkene ohne weitere Substituenten an der Doppelbindung erreicht. Acetylaceton und 2,3-Dihydro-1-oxo-1H-inden-2-carbonsäuremethylester werden alsMichael-Donoren und vier Cinchona-Alkaloide als chirale basische Katalysatoren verwendet. Die Bestimmung des Enantiomerenüberschusses wird mittels1H-NMR-Spektroskopie in Gegenwart vonPirkle-Alkohol und HPLC an chiralen stationären Phasen durchgeführt. Eine Korrelation zwischen der relativen Konfiguration der Vorzugsisomeren derMichael-Addukte und den Katalysatoren wurde hergestellt.
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3.
The Morita-Baylis-Hillman reaction (MBHR) of conjugated nitroalkenes has been successfully carried out for the first time. A variety of aromatic and heteroaromatic nitroalkenes react with formaldehyde at room temperature in the presence of stoichiometric amounts of imidazole and catalytic amounts of anthranilic acid in THF providing moderate to good yields of the multifunctional adducts in most of the cases.  相似文献   
4.
Asymmetric conjugate addition of arylboronic acids to 2-nitroacrylamide in the presence of cationic palladium–Chiraphos complex proceeds with high yield and enantioselectivity (73–89% ee) using as low as 0.05–0.25 mol % of the catalyst. The adducts can be smoothly transformed into the corresponding β2-homophenylglycines in two simple steps.  相似文献   
5.
A flexible approach to hexahydronaphthalene-1-carboxylates based on the Favorskii rearrangement of 1,1-dichloro bicyclo[5.4.0]undec-5-en-2-ones has been devised. 1,1-Dichloro bicyclo[5.4.0]undec-5-en-2-ones can be prepared from readily available cyclohexanones by a short sequence.  相似文献   
6.
A highly efficient asymmetric Michael addition of anthrone to nitroalkenes catalyzed by cinchona alkaloids was described. Up to 99% ee of the corresponding adduct was obtained.  相似文献   
7.
A novel [4 + 1] cycloaddition protocol for the synthesis of dihydrobenzo(naphtho)furan skeletons from readily available 2-(2-nitrovinyl)-phen(naphth)ols and malonate esters via a tandem Michael addition/iodine-catalyzed oxidative annulation has been developed. This method provides a new and facile application of malonate esters as 1,1-nucleophilic/electrophilic type C1 synthons without a pre-functionalization step and the plausible reaction mechanism is proposed.  相似文献   
8.
An approach to conjugated nitroalkenes via oxidation of N,N-bis(silyloxy)enamines with bromine or iodine in the presence of tetra-n-butylammonium acetate is described. The acetate ion plays a key role by acting as a mild desilylating reagent. This new strategy allows the synthesis of α-nitroalkenes from the corresponding nitroalkanes.  相似文献   
9.
Secondary acyclic formamide serves as an efficient nucleophile to nitroalkenes to give corresponding Michael adducts in good yields. The nitro group in the adducts was useful for further heterocyclic synthesis.  相似文献   
10.
The Michael addition of ketone-derived enamines, metalated methylene active compounds and N-methyl pyrroles to γ-fluoro-α-nitroalkenes provided in moderate to good isolated yields the corresponding β-fluoroalkyl nitro compounds, which represent new interesting, highly functionalized building blocks in organofluorine chemistry.  相似文献   
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