Screening of anti-HIV-1 inophyllums by HPLC-DAD of Calophyllum inophyllum leaf extracts from French Polynesia Islands

Various pyranocoumarins, calophyllolide, inophyllums B, C, G₁, G₂ and P, from Calophyllum inophyllum (Clusiaceae) leaves of French Polynesia (Austral, Marquesas, Society and Tuamotu archipelagos) have been determined in 136 leaf extracts using a high pressure liquid chromatography-UV-diode array detection (HPLC-UV-DAD) technique. Results show a wide range in chemical composition within trees growing on eighteen islands. The use of multivariate statistical analyses (PCA) shows geographical distribution of inophyllums and indicate those rich in HIV-1 active (+)-inophyllums. Inophyllum B and P contents (0.0-39.0 and 0.0-21.8 mg kg⁻¹, respectively) confirm the chemodiversity of this species within the large area of French Polynesia. The study suggests the presence of interesting chemotypes which could be used as plant source for anti-HIV-1 drugs.     

Synthesis of pyrano[2,3-<Emphasis Type="Italic">f</Emphasis>]chromen-2,8-diones and pyrano[3,2-<Emphasis Type="Italic">g</Emphasis>]chromen-2,8-diones based on <Emphasis Type="Italic">o</Emphasis>-hydroxyformyl(acyl)neoflavonoids

Novel pyrano[2,3-f]chromen-2,8-diones and pyrano[3,2-g]chromen-2,8-diones were prepared based on modified analogs of natural o-hydroxyformyl(acyl)neoflavonoids. __________ Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 15–20, January–February, 2008.     

Trifluoromethanesulfonic acid mediated Friedel-Crafts reaction of (E)-3-aryl-2-(diethoxyphosphoryl)acrylic acids with electron-rich hydroxyarenes. A convenient approach to α-methylene-δ-valerolactones

The synthesis of trans-3-diethoxyphosphoryl-4-aryl-3,4-dihydrocoumarins from electron-rich hydroxyarenes and (E)-3-aryl-2-(diethoxyphosphoryl)acrylic acids has been achieved by using CF₃SO₃H as a catalyst. The products could be easily transformed to the corresponding α-methylene-δ-valerolactones by means of the Horner-Wadsworth-Emmons reaction.