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Jennifer Albaneze-Walker Jerry A. Murry Arash Soheili Scott Ceglia Shawn A. Springfield Charles Bazaral Peter G. Dormer David L. Hughes 《Tetrahedron》2005,61(26):6330-6336
An efficient synthesis of a potent PDE IV inhibitor 1 is described. The synthesis is highlighted by two practical and efficient catalytic reactions: a highly selective catalytic palladium mediated carbonylation of the pyridine side chain and an efficient palladium-catalyzed Suzuki-Miyaura coupling of a chloropyridine-N-oxide. 相似文献
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Rémy Morgentin Georges Pasquet Pascal Boutron Frédéric Jung Maryannick Lamorlette Mickaël Maudet Patrick Plé 《Tetrahedron》2008,64(12):2772-2782
This paper describes the different strategies devised and applied to overcome the selectivity issues in the syntheses of 6,7-disubstituted-1H-quinolin-4-one, 7-substituted-1H-1,6-naphthyridin-4-one and 6-substituted-1H-1,7-naphthyridin-4-one derivatives. They allowed us to improve the overall yields and the scaling-up feasibility. Several examples illustrate these strategies with their advantages and drawbacks. 相似文献
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Lian-Shun FengMing-Liang Liu Shuo WangYun Chai Kai LvGuang-Zhi Shan Jue CaoSu-Jie Li Hui-Yuan Guo 《Tetrahedron》2011,67(43):8264-8270
The synthesis of naphthyridone derivatives containing 8-alkoxyimino-1,6-dizaspiro[3.4]octane scaffolds, the position isomers of the side chain at the C-7 position of Zabofloxacin, has been achieved in eight steps from tert-butyl 3-cyano-4-oxopyrrolidine-1-carboxylate. The possible reaction mechanisms were also proposed. The key spirocyclic carbamate esters, which could be prepared using a modified Hofmann rearrangement strategy, were condensed with naphthyridone nuclei, and the resulting condensates were easily cleaved by TMSI and subsequently cyclized in the presence of K2CO3. Moreover, additional N-methylation derivatives were also obtained using the synthetic sequence. 相似文献
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