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Jingjing Han Kai Liu Rui Chang Luyang Zhao Xuehai Yan 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2019,131(7):2022-2026
Enzyme mimics have broad applications in catalysis and can assist elucidation of the catalytic mechanism of natural enzymes. However, challenges arise from the design of catalytic sites, the selection of host molecules, and their integration into active three‐dimensional structures. Herein, we describe the development of a photooxidase mimic by synergetic molecular self‐assembly. 9‐Fluorenylmethyloxycarbonyl‐l ‐histidine undergoes efficient co‐assembly with phthalocyanine into nanovesicles with tunable particle size and membrane thickness. The obtained nanovesicles can be used as catalysts for reactive‐oxygen‐mediated photosensitive oxidation with improved efficiency and stability. This work highlights the co‐assembly of simple building blocks into a supramolecular photocatalyst, which might give insight into possible evolutionary paths of photocatalytic membrane systems, and might allow facile transfer into photosensitive nanoreactors or artificial organelles. 相似文献
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Debabrata Samanta Syamantak Roy Ranjan Sasmal Nilanjana Das Saha Pradeep KR Ranjani Viswanatha Sarit S. Agasti Tapas Kumar Maji 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2019,131(15):5062-5066
A solvent responsive dynamic nanoscale metal‐organic framework (NMOF) [Zn( 1 a )(H2O)2] has been devised based on the self‐assembly of ZnII and asymmetric bola‐amphiphilic oligo‐(p‐phenyleneethynylene) (OPE) dicarboxylate linker 1 a having dodecyl and triethyleneglycolmonomethylether (TEG, polar) side chains. In THF solvent, NMOF showed nanovesicular morphology ( NMOF‐1 ) with surface decorated dodecyl chains. In water and methanol, NMOF exhibited inverse‐nanovesicle ( NMOF‐2 ) and nanoscroll ( NMOF‐3 ) morphology, respectively, with surface projected TEG chains. The pre‐formed NMOFs also unveiled reversible solvent responsive transformation of different morphologies. The flexible NMOF showed cyan emission and no cytotoxicity, allowing live cell imaging. Cisplatin (14.4 wt %) and doxorubicin (4.1 wt %) were encapsulated in NMOF‐1 by non‐covalent interactions and, in vitro and in vivo drug release was studied. The drug loaded NMOFs exhibited micromolar cytotoxicity. 相似文献
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Jorge Royes Oana Ilioaia Quentin Lubart Federica Angius Galina V. Dubacheva Marta Bally Bruno Miroux Christophe Tribet 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2019,131(22):7473-7477
Despite growing research efforts on the preparation of (bio)functional liposomes, synthetic capsules cannot reach the densities of protein loading and the control over peptide display that is achieved by natural vesicles. Herein, a microbial platform for high‐yield production of lipidic nanovesicles with clickable thiol moieties in their outer corona is reported. These nanovesicles show low size dispersity, are decorated with a dense, perfectly oriented, and customizable corona of transmembrane polypeptides. Furthermore, this approach enables encapsulation of soluble proteins into the nanovesicles. Due to the mild preparation and loading conditions (absence of organic solvents, pH gradients, or detergents) and their straightforward surface functionalization, which takes advantage of the diversity of commercially available maleimide derivatives, bacteria‐based proteoliposomes are an attractive eco‐friendly alternative that can outperform currently used liposomes. 相似文献
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