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Sisi Ling Xiaohu Yang Dr. Chunyan Li Yejun Zhang Dr. Hongchao Yang Dr. Guangcun Chen Prof. Qiangbin Wang 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2020,132(18):7286-7290
Activatable theranostic systems show potential for improved tumor diagnosis and therapy owing to high detection specificities, effective ablation, and minimal side-effects. Herein, a tumor microenvironment (TME)-activated NIR-II nanotheranostic system (FEAD1) for precise diagnosis and treatment of peritoneal metastases is presented. FEAD1 was fabricated by self-assembling the peptide Fmoc-His, mercaptopropionic-functionalized Ag2S quantum dots (MPA-Ag2S QDs), the chemodrug doxorubicin (DOX), and NIR absorber A1094 into nanoparticles. We show that in healthy tissue, FEAD1 exists in an NIR-II fluorescence “off” state, because of Ag2S QDs-A1094 interactions, while DOX remains in stealth mode. Upon delivery of FEAD1 to the tumor, the acidic TME triggers its disassembly through breakage of the Fmoc-His metal coordination and DOX hydrophobic interactions. Release of A1094 switches on Ag2S fluorescence, illuminating the tumor, accompanied by burst release of DOX within the tumor tissue, thereby achieving precise tumor theranostics. This TME-activated theranostic strategy holds great promise for future clinical applications. 相似文献
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Guocan Yu Tian‐Yong Cen Zhimei He Shu‐Ping Wang Zhantong Wang Xin‐Wen Ying Shijun Li Orit Jacobson Sheng Wang Lei Wang Li‐Sen Lin Rui Tian Zijian Zhou Qianqian Ni Xiaopeng Li Xiaoyuan Chen 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2019,131(26):8891-8895
Single molecular nanoparticles (SMNPs) integrating imaging and therapeutic capabilities exhibit unparalleled advantages in cancer theranostics, ranging from excellent biocompatibility, high stability, prolonged blood lifetime to abundant tumor accumulation. Herein, we synthesize a sophisticated porphyrin nanocage that is further functionalized with twelve polyethylene glycol arms to prepare SMNPs ( porSMNPs ). The porphyrin nanocage embedded in porSMNPs can be utilized as a theranostic platform. PET imaging allows dynamic observation of the bio‐distribution of porSMNPs , confirming their excellent circulation time and preferential accumulation at the tumor site, which is attributed to the enhanced permeability and retention effect. Moreover, the cage structure significantly promotes the photosensitizing effect of porSMNs by inhibiting the π–π stacking interactions of the photosensitizers, ablating of the tumors without relapse by taking advantage of photodynamic therapy. 相似文献
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