Non‐Alkaloidal Constituents from the Stem of Ficus Septica

Seven triterpenes, two lignans, and twelve other known compounds were isolated from the non‐alkaloidal fractions of the stem of Ficus septica Among these triterpenoids, a rare triterpene skeleton derivative, 13,27‐cycloursan‐3β‐ylacetate was isolated from natural sources for the first time. All the structures of these compounds were elucidated by spectroscopic methods.     

New 2-arylbenzofurans from the root bark of Artocarpus gomezianus and their α-glucosidase inhibitory activity

Two new 2-arylbenzofurans, namely 13-O-methyllakoochin B (1) and artogomezianin (2), were isolated from the root bark of Artocarpus gomezianus, along with six known compounds (3–8). The structures of new compounds were determined by spectroscopic and chemical methods. All of the isolates were evaluated for their α-glucosidase inhibitory activity. Artogomezianin (2) and lakoochin A (3) exhibited strong α-glucosidase inhibitory activity with IC₅₀ values of 18.25 and 26.19 µM, respectively, as compared with the positive control acarbose.     

A novel antimicrobial triterpenic acid from the leaves of Ficus benjamina (var. comosa)

The chloroform extract of the leaves of Ficus benjamina (var. comosa) (Moraceae) afforded a new triterpenic acid named as (9,11), (18,19)-disecoolean-12-en-28-oic acid (1) along with β-amyrin (2). Their structures were established on the basis of chemical and physical evidences (IR, ¹H NMR, and MS data). The compound 1 exhibited significant antimicrobial activity against Salmonella typhimurium (MTCC-98), Candida albicans (IAO-109), Staphylococcus aureus (IAO-SA-22), Escherichia coli (K-12) and low activity against Aspergillus niger (lab isolate ICAR) and Aspergillus brassicola.     

New Prenylated Flavones from the Roots of Ficus Beecheyana

Two new prenylated flavanones, ficubee A and ficubee B, respectively, as 7,8‐(2,2‐dimethylpyrano)‐6‐prenyl‐5,3′,4′‐trihydroxyflavone and 6,7‐(2,2‐dimethylpyrano)‐8‐prenyl‐5,3′,4′‐trihydroxyflavone were isolated from the roots of Ficus beecheyana together with twelve known compounds: β‐sitosterol, 5‐stigmasten‐3β,7α‐diol, 5‐stigmasten‐3β,7β‐diol, 3β‐hydroxystigmast‐5‐en‐7‐one, 4‐hydroxybenzaldehyde, 4‐hydroxy‐3‐methoxybenzaldehyde, 1‐(4‐hydroxyphenyl)‐ethanone, 4‐hydroxy‐3‐methoxybenzoic acid, 4‐hydroxy‐cinnamic acid, seseline, xanthyletin, and psoralene. The structures of these secondary metabolites were determined by spectroscopic means and in comparison with published data.     

Analysis of furanocoumarins from Yemenite Dorstenia species by liquid chromatography/electrospray tandem mass spectrometry

A series of prevailing prenylated furanocoumarins from leaves of Dorstenia gigas and Dorstenia foetida (Moraceae) were investigated by liquid chromatography/electrospray tandem mass spectrometry. The mass spectral behavior of the furanocoumarins under positive ion electrospray conditions is discussed using both an ion trap and a triple quadrupole system. It is demonstrated that both methods represent valuable tools not only for the rapid classification of this type of compounds, but also with respect to their substitution pattern. Copyright © 2012 John Wiley & Sons, Ltd.     

HPLC-DAD Quantification of Phenolic Compounds Contributing to the Antioxidant Activity of Maclura pomifera,Ficus carica and Ficus elastica Extracts

Abstract

The concentration and antioxidant activity of the known phenolics macluraxanthone, rutin, chlorogenic acid, and psoralen present in M. pomifera, F. carica, and F. elastica extracts were determined to evaluate the plant extracts potency as new antioxidant suppliers.

The quantification of the compounds was obtained by HPLC-DAD. The antioxidant activity of plant extracts and compounds was evaluated using DPPH and ABTS methods. The results seem to indicate that these extracts can be promising as new antioxidant suppliers, particularly F. carica and F. elastica leaves because only about 30% and about 50%, respectively, of the total activity was due to the phenolics determined.     

A new cytotoxic cardenolide from the latex of Antiaris toxicaria

A new cardenolide,toxicarioside E(1),was isolated from the latex ofAntiaris toxicaria(Pers.) Lesch(Moraceae).Its structure was elucidated on the basis of spectral data and chemical evidence.Compound 1 showed significant cytotoxicity against K562 and SGC-7901 cell lines in vitro by MTT method with the IC_(50) value of 0.026 and 0.027μg/mL,respectively.     

Molecular diversity of Artocarpus champeden (Moraceae): A species endemic to Indonesia

A summary of results obtained in the study of natural products isolated from a Moraceae species Artocarpus champeden is presented. The various classes of 3-prenylflavonoids isolated and the biogenetical correlation between the metabolites are discussed. Some of the flavonoids exhibited strong cytotoxicity against murine leukemia P388 cell lines, suggesting that flavonoids derived from moraceous plants represent a plausible unexplored resource of novel antitumor leads.     

Analysis of antioxidant flavonoids from asteraceae and moraceae plants by capillary electrophoresis

Summary Antioxidant flavonoids from the plantsSolidago gigantea Ait.,Taraxacum officinale Wiggers and Webers (Asteraceae) andMorus nigra L. (Moraceae) have been analysed by capillary electrophoresis (CE).Solidago gigantea was investigated because of its diuretic, spasmolytic, antiphlogistic, and wound-healing effect,Taraxacum officinale because it has been shown to have good diuretic and choleretic activity, andMorus nigra because it is also widely regarded as a diuretic and antidiabetic agent. Aqueous and methanolic extracts of these plants have antioxidant properties. Because their flavonoid composition might be important in their free-radical-scavenging activity, a capillary electrophoretic method was developed for characterization of the flavonoids present. We identified quercetin-3-O-β-rutinoside (rutin), quercetin-3-O-β-d-glucoside (isoquercitrin), and chlorogenic acid as the most abundant compounds inSolidago gigantea andMorus nigra, and apigenin-7-O-β-glucoside, luteolin-7-O-β-glucoside, and chlorogenic acid inTaraxacum officinale. We also discovered that quercetin-3-O-α-rhamnoside (quercitrin) and quercetin-3-O-β-galactoside (hyperoside) were absent from our sample ofSolidago gigantea and quercitrin fromMorus nigra. Quantitative analysis of these extracts was performed by high-performance liquid chromatography (HPLC). Presented at Balaton Symposium '01 on High-Performance Separation Methods, Siófok, Hungary, September 2–4, 2001     

Two new phenolic constituents from the root bark of Morus alba L. and their cardioprotective activity

A new biphenyl-furocoumarin, named morescoumarin A (1), and a new prenylated flavanone, named morflavanone A (2) were isolated from the root bark of Morus alba L., together with four known compounds (3–6). Their structures were determined by extensive spectroscopic analyses and comparison with literature data. The cardioprotective effects of these compounds against doxorubicin-induced cell death were evaluated by MTT method.