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Applications of microelectromechanical systems (MEMS) technology are widespread in both industrial and research fields providing
miniaturized smart tools. In this review, we focus on MEMS applications aiming at manipulations and characterization of biomaterials
at the single molecule level. Four topics are discussed in detail to show the advantages and impact of MEMS tools for biomolecular
manipulations. They include the microthermodevice for rapid temperature alternation in real-time microscopic observation,
a microchannel with microelectrodes for isolating and immobilizing a DNA molecule, and microtweezers to manipulate a bundle
of DNA molecules directly for analyzing its conductivity. The feasibilities of each device have been shown by conducting specific
biological experiments. Therefore, the development of MEMS devices for single molecule analysis holds promise to overcome
the disadvantages of the conventional technique for biological experiments and acts as a powerful strategy in molecular biology.
Figure Towards single bio molecular handling and characterization by MEMS 相似文献
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