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Application of capillary electrophoresis (CE) as a high-resolution separation technique in metalloproteomics research is critically
reviewed. The focus is on the requirements and challenges involved in coupling CE to sensitive element and molecule-specific
detection techniques such as inductively coupled plasma mass spectrometry (ICP–MS) or electrospray ionisation mass spectrometry
(ESI–MS). The complementary application of both detection techniques to the structural and functional characterisation of
metal-binding proteins and their structural metal-binding moieties is emphasised. Beneficial aspects and limitations of mass
spectrometry hyphenated to CE are discussed, on the basis of the literature published in this field over the last decade.
Recent metalloproteomics applications of CE are reviewed to demonstrate its potential and limitations in modern biochemical
speciation analysis and to indicate future directions of this technique. 相似文献
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