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Kuniaki Tatsuta Hiroaki Tanaka Hitomi Tsukagoshi Takafumi Kashima Seijiro Hosokawa 《Tetrahedron letters》2010,51(42):5546-5549
The total synthesis of lactonamycin has been achieved. The synthesis includes sequential intramolecular conjugate addition of alcohols to the acetylenic ester, stereoselective glycosylation of the tertiary alcohol, and Michael-Dieckmann type cyclization with the thioester, by which the highly convergent route has been established. 相似文献
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The synthesis of dihydroxy-isoindolinone-carboxylates from a dioxinone keto-ester and N-protected sarcosine without the use of phenolic protection is described. Base-induced aromatization of the dioxinone diketo-ester followed by lactamization furnished the desired dihydroxy-isoindolinone moiety, which could be used as an EF-ring precursor toward the synthesis of lactonamycin. 相似文献
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The conjugate addition reactions of protected pyranose alkoxides to both nitroalkenes and nitrosoalkenes, as a route to 2-nitroalkyl, 2-oximinoalkyl and 2-oxoalkyl glycosides, are described. 相似文献
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Philip J. Parsons Jonathan Board Davide Faggiani Peter B. Hitchcock Lewis Preece Alexander J. Waters 《Tetrahedron》2010,66(33):6526-6075
A new and highly efficient route for the construction of a model for the synthesis of lactonamycin 1 is reported. The chemistry has been utilised for the synthesis of heterocyclic rings, and new reactions for the synthesis of dienes and alkynes are reported. 相似文献
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Ronan Le Vzouët Andrew J.P. White Jeremy N. Burrows Anthony G.M. Barrett 《Tetrahedron》2006,62(52):12252-12263
Both (1) furan–maleimide Diels–Alder cycloaddition reaction and (2) furan–benzyne cycloaddition, Suzuki cross-coupling, boron-mediated aldol, and electrophilic aromatic substitution reactions were examined for the construction of the CDEF ring system of lactonamycin (1). 相似文献
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