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Jian‐Xia Mo Yang Bai Bo Liu Chang‐Xin Zhou Li Zou Li‐She Gan 《Helvetica chimica acta》2014,97(6):887-894
Two new cycloartane triterpenoids, (23R)‐21,23:23,27‐diepoxycycloarta‐1,24‐diene‐3,27‐dione ( 1 ) and (3α)‐(α‐L ‐arabinopyranosyloxy)‐1α‐hydroxy‐23‐oxocycloartan‐28‐oic acid ( 2 ), together with six known pentacyclic triterpenoids, 3 – 8 , and five known C29 steroids, 9 – 13 , were isolated from Kleinhovia hospita. The structures of these compounds were determined by analysis of their spectroscopic data. Moreover, the absolute configuration of 1 was confirmed by quantum‐chemical TDDFT calculation of its ECD spectrum. All compounds were evaluated for their cytotoxic activities against human colon carcinoma (HCT116) and gastric carcinoma (SGC7901) cell lines, and compounds 6, 7, 8, 11 , and 12 exhibited antiproliferative activities with IC50 values ranging from 23.0 to 91.8 μM . 相似文献
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