Genetic profile characterization and population study of 21 autosomal STR in Chinese Kazak ethnic minority group

Short tandem repeat loci have been recognized as useful tools in the routine forensic application and in recent decades, more and more new short tandem repeat (STR) loci have been constantly discovered, studied, and applied in forensic caseworks. In this study, we investigated the genetic polymorphisms of 21 STR loci in the Kazak ethnic minority as well as the genetic relationships between the Kazak ethnic minority and other populations. Allelic frequencies of 21 STR loci were obtained from 114 unrelated healthy Kazak individuals in the Ili Kazak Autonomous Prefecture, Xinjiang Uigur Autonomous Region of China. We observed a total of 159 alleles in the group with the allelic diversity values ranging from 0.0044 to 0.5088. The highest polymorphism was found at D19S433 locus and the lowest was found at D1S1627. Statistical analysis of the generated data indicated no deviation from Hardy–Weinberg equilibriums at all 21 STR loci. In order to estimate the population differentiation, allelic frequencies of all STR loci of the Kazak were compared with those of other neighboring populations using analysis of molecular variance method. Statistically significant differences were found between the studied population and other populations at 2–7 STR loci. A neighbor‐joining tree was constructed based on allelic frequencies of the 21 STR loci and phylogenetic analysis indicates that the Kazak has a close genetic relationship with the Uigur ethnic group. The present results may provide useful information for forensic sciences and population genetics studies, and can also increase our understanding of the genetic background of this group. The present findings showed that all the 21 STR loci are highly genetically polymorphic in the Kazak group, which provided valuable population genetic data for the genetic information study, forensic human individual identification, and paternity tests.     

支持维、哈、柯文的Web浏览器的研究与实现

本文主要是针对网页浏览器在其界面和功能方面的不足,保留了现有Web浏览器所具备的所有功能的基础上,在Windows平台下,设计并开发出基于IE内核的具有维、哈、柯文特色的Web浏览器。主要内容包括了介绍向浏览器中嵌入维、哈、柯文字库及输入法技术,实现网页地址转换和文种转换等功能,在浏览器上实现汉、维、哈、柯四种语言来支持用户的使用需求。     

新疆各族大学生ABO血型分布的研究

调查了新疆大学主要三个民族的大学生ABO血型，结果表明：本校学生ABO血型频率依次为O〉B〉A〉AB，在维吾尔族学生中血型频率分布依次为B型（30．23oA）、A型（29．96％）、O型（25．91％）、AB型（13．90oA），基因频率为r（0．4968）〉q（0．2525）〉p（0．2507）．各表型分布的观察值与期望值间均无显著性差异（P〉0．1）；汉族学生中血型频率分布依次为O型（31．02％）、B型（29．77％）、A型（28．22oA）、AB型（10．99oA），基因频率为r（0．5494）〉q（0．2303）〉p（O．2203）．各表型分布的观察值与期望值问无显著性差异（P〉0．1）；哈萨克族学生中血型频率分布以次为O型（36．36oA）、B型（27．27％）、A型（26．09%）、AB型（10．28％），基因频率为r（0．588O）〉q（0．2097））〉p（0．2023），各表型分布的观察值与期望值间均无显著性差异（P〉0．1）．在学科分类来观察大学生ABO血型之间差异显著．     

Development of a novel multiplex polymerase chain reaction system for forensic individual identification using insertion/deletion polymorphisms

Insertion/deletion (InDel) polymorphisms have been widely used in the fields of population genetics, genetic map constructions, and forensic investigations owing to the advantages of their low mutation rates, widespread distributions in the human genome, and small amplicon sizes. In order to provide more InDels with high discrimination power in Chinese populations, we selected and constructed one novel multiplex PCR‐InDel panel for forensic individual identification. Genetic distributions of these 35 InDels in five reference populations from East Asia showed low genetic differentiations among these populations. Forensic efficiency evaluations of these InDels revealed that these loci could perform well for forensic individual identifications in these reference populations. In the meantime, genetic diversities and forensic parameters of these InDels were further investigated in the studied Kazak group. Mean value of polymorphism information content for 35 InDels was 0.3611. Cumulative power of discrimination of 35 InDels was 0.99999999999999603 in Kazak group. Given these results, the panel is suitable for individual identifications in the studied Kazak and these reference populations.     

130名哈萨克族牧民血清铁、血红蛋白含量与高血压关系的分析

为探讨乌鲁木齐南山130名哈萨克族牧民血清铁及血红蛋白含量与原发性高血压的关系,给哈萨克族原发性高血压的病因学研究提供科学依据,对这些牧民进行了血压测定和血清铁、血红蛋白含量分析。结果表明,130名哈萨克族牧民高血压检出率为53.3%;高血压组血清铁水平明显高于正常组(P=0.000);高血压组血红蛋白含量也明显高于正常组(P=0.004);进一步分析表明,高血压组男性和女性血清铁水平明显高于正常组男性和女性(P0.01和P0.001);血红蛋白含量高血压组女性较正常血压组女性高,差异有统计学意义(P0.05),而男性两组差异不明显。提示哈萨克族高血压患者血清铁和血红蛋白的含量与高血压的发生可能有关。