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1.
Shengbao Diao Mei Jin Jinfeng Sun Yi Zhou Chao Ye Yong Jin 《Natural product research》2019,33(5):701-707
A new diarylheptanoid, (2S,3S,5S)-2,3,5-trihydroxy-1,7-bis(4-hydroxy- 3-methoxyphenyl)heptane (1), and a new diarylheptanoid glycoside, (2S,3S,5S)-2,3-dihydroxy-5-O-β-d-xylopyranosyl-7-(4-hydroxy-3-methoxyphenyl)-1-(4-hydroxyphenyl)heptane (2), together with three known compounds, rhoiptelol C (3), rhoiptelol B (4) and 3′,4″-epoxy-2-O-β-d-glucopyanosyl-1-(4-hydroxyphenyl)- 7-(3-methoxyphenyl)heptan-3-one (5) were isolated from the roots of Juglans mandshurica (Juglandaceae). The structures of compounds 1 and 2 were identified based on HR-ESI-MS, 1D and 2D NMR spectroscopic methods. Compounds 1–5 were assayed for their inhibitory effects on the production of NO, TNF-α and IL-6 in LPS-stimulated RAW264.7 cells. 相似文献
2.
Phytochemical study of green walnut husks of Juglans mandshurica Maxim. led to the isolation of a new naphthalenone, (4R)-3,4-dihydro-4-butoxy-5-hydroxy-naphthalen-1(2H)-one (1), together with 16 known compounds. Compounds 4–6, 13, 14 and 17 were isolated from the genus Juglans for the first time, and their chemotaxonomic significance was also evaluated. 相似文献
3.
One new diarylheptanoid (3S)-3′, 4″-epoxy-1-(4′-hydroxylphenyl)-7-(3″-hydroxylphenyl) heptane-3-hydroxy (1), together with eleven known ones (2–12), was isolated from the fresh pericarps of Juglans sigillata. Their structures were elucidated on the basis of extensive spectroscopic methods, including HR-ESI-MS, 1D and 2D-NMR. All isolates were evaluated for their cytotoxic activities in vitro against the growth of human cancer cells lines HT-29 and MCF-7 by MTT assay. 相似文献
4.
《Arabian Journal of Chemistry》2023,16(1):104441
Fourteen previously unreported 3,4-seco-dammarane triterpenoids named Qingqianliusus A-N (1–14), along with four known 3,4-seco-dammarane triterpenoid derivatives (15–18) were isolated from the 95 % ethanol extract of the Cyclocarya paliurus leaves. Compounds 1 and 2 possess a rare 3,11-heptacyclic lactone as natural product, and several pairs of the 3,4-seco-dammarane triterpenoid epimers with R/S configuration at C-24 were investigated and determined in detail for the first time. Compounds 8, 11, and 14 showed good α-glucosidase inhibitory effects with IC50 values of 4.97 ± 0.63, 7.08 ± 0.53, and 3.76 ± 0.77 μM, respectively. Meanwhile, compound 11 was also found potent inhibition rate of 35.83 % against COX-2, as compared with the positive control celecoxib (70.28 %). In addition, compounds 3, 7, 10, and 13 exhibited outstanding cytotoxicities against human gastric cancer cell lines (BGC-823) with IC50 values of 7.69 ± 0.21, 8.47 ± 0.41, 9.04 ± 0.61, and 8.86 ± 0.38 μM, respectively. Compounds 13 and 3 had modest activities on human colon cancer cell lines (HCT-116) with IC50 values of 8.80 ± 0.36 and 9.45 ± 0.93 μM, respectively. 相似文献
5.
Zhe Jiang Shengbao Diao Ren Li Wei Zhou Jinfeng Sun Yi Zhou 《Natural product research》2018,32(9):1017-1021
A new 1,4-napthoquinone derivative, namely (S)-(-)-3-(8-hydroxy-1,4-dioxo-1,4-dihydro-naphthalen-2-yl)-3-(4-hydroxy-3-methoxyphenyl)-propionic acid methyl ester (1), was isolated from the roots of Juglans mandshurica Maxim. The structure was identified based on HR-ESI-MS, 1D and 2D NMR spectroscopic methods. 相似文献
6.
Anti—diabetes Agents—I:Tetralone Derivative from Juglans regia 总被引:1,自引:0,他引:1
TianYingAN LiHongHU RongMinCHEN ZhongLiangCHEN JiaLI QiangSHEN 《中国化学快报》2003,14(5):489-490
A new compound,4-hydroxy-α-tetralone-4-O-β-D-[6‘‘‘‘‘‘‘‘-O-(3“,4“,5“-trihydroxybenzoyl)glucopyranoside(1),together with a known compound,4-hydroxy-α-tetralone(2),has been isolated from the roots of Juglans regia.2 showed moderate bioactivity against protein tyrosine phosphatase 1B(PTP1B). 相似文献
7.
Hong Bing LIU Cheng Bin CUI * Bing CAI Qian Qun GU Dong Yun ZHANG Qing Chun ZHAO Hua Shi GUAN Key Laboratory of Marine Drugs Ministry of Education China Marine Drug Food Institute Ocean University of China Qingdao Tianjin Institute for Biomedicinal Research 《中国化学快报》2005,16(2):215-218
Pterocarya tonkinesis(Franch.)Dode.(Juglandaceae)forms a typical community ofriverside season rain forest in Xishuangbanna area of Yunnan province1.The same genusplant P.stenoptera C.DC.,has long been used as a traditional Chinese herbal medicine2and P.tonkinesis,itself,is also used as a folk medicine for the treatment of certain cancersin partial area of China.However,no report had so far been seen on the chemicalconstituents and their biological activities of the title plant yet.In the … 相似文献
8.
Two new secodammarane triterpenoid saponins, cyclocariosides I and J (1 and 2), and a new epoxydammarane triterpenoid saponin, cyclocarioside K (3) were isolated from the ethanol extracts of the leaves of Cyclocarya paliurus. The structures of these compounds were elucidated by spectroscopic techniques. 相似文献
9.
Mei Jin Shengbao Diao Changhao Zhang Shuo Cao Jinfeng Sun Ren Li 《Natural product research》2015,29(19):1839-1844
Two new diarylheptanoids, ( ? )-threo-3′,4″-epoxy-1-(4-hydroxyphenyl)-7-(3-methoxyphenyl)heptan-2,3-diol (1) and (1α,3β,5α,6α)-1,5-epoxy-3,6-dihydroxy-1,7-bis(3-methoxy-4-hydroxy-phenyl)-heptane (2), along with one known diarylheptanoid, rhoiptelol B (3), were isolated from the roots of Juglans mandshurica. The structures of compounds 1 and 2 were identified based on HR-ESI-MS, 1D and 2D NMR including 1H–1H COSY, HMQC, HMBC and NOESY spectroscopic methods. 相似文献
10.
Wen-bing Ding Rui-yuan Zhao Guan-hua Li Bing-lei Liu Hua-liang He Lin Qiu Jin Xue You-zhi Li 《Molecules (Basel, Switzerland)》2020,25(24)
Five new cyclic diarylheptanoids (platycary A–E, compounds 1–5) and three previously identified analogues (i.e., phttyearynol (compound 6), myricatomentogenin (compound 7), and juglanin D (compound 8)) were isolated from the stem bark of Platycarya strobilacea. The structures of these compounds were determined using NMR, HRESIMS, and electronic circular dichroism (ECD) data. The cytotoxicity of compounds 1–5 and their ability to inhibit nitric oxide (NO) production, as well as protect against the corticosterone-induced apoptosis of Pheochromocytoma (PC12) cells, were evaluated in vitro using the appropriate bioassays. Compounds 1 and 2 significantly inhibited the corticosterone-induced apoptosis of PC12 cells at a concentration of 20 μΜ. 相似文献