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Silyl triflate-accelerated additions of catalytically generated zinc acetylides to N-phenyl nitrones
Terminal alkynes readily form zinc acetylides in the presence of iPr2NEt and 20 mol % ZnBr2, then attack N-phenyl nitrones activated by trimethylsilyl trifluoromethanesulfonate. Deprotection with aqueous acid yields N-hydroxyl propargylamine. Yields are generally high for nitrones derived from aromatic aldehydes. Control experiments suggest that silyl triflate has a significant accelerating effect upon the reaction. 相似文献
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