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Two dimeric grayanane diterpenes with a novel 3-O-2 linkage, birhodomolleins D (1) and E (2), were isolated and structurally elucidated from the fruits of Rhododendron pumilum. Their structures were fully determined by comprehensive analysis of spectroscopic data. 相似文献
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Chang-Shan Niu Yong Li Yun-Bao Liu Shuang-Gang Ma Fei Liu Li Cui Hai-Bo Yu Xiao-Jing Wang Jing Qu Shi-Shan Yu 《Tetrahedron》2018,74(3):375-382
During our continuing study on the roots of Pieris formosa, twelve new grayanane diterpenoids (1–12), together with eight known compounds (13–20), were obtained. Their structures with absolute configurations were characterized by a series of spectroscopic methods and X-ray diffraction. Compounds 1, 2, 4–5, 7–8, 14, and 19 exhibited significant analgesic activity in an acetic acid-induced writhing test. In particular, 7 and 14 were found to be 5 times more potent than morphine in the acetic acid-induced writhing test model. Compounds 1, 4, 9, 13, and 18 showed antifeedant activity against Plutella xylostella at 0.5 mg/mL. Compound 4 exhibited a 38.3% inhibitory effect against the KCNQ2 potassium channel at a concentration of 10 μM. 相似文献
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Birhodomolleins A-C (1-3), three novel diterpenoids dimerized from two grayanane diterpenes through an oxygen bridge, were isolated from the flowers of Rhododendron molle. Their structures were elucidated by interpretation of their 1D and 2D NMR and other spectroscopic data. Birhodomollein A (1) contains a rare chloro-substitution on one of the grayanane moieties. These are the first examples of dimeric diterpenes from the Ericaceae family. 相似文献
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