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XU Yizhuang Yang Limin XU Zhi ZHAO Ying LING Xiaofeng Li Qingbo Wang Jiansheng Zhang Nengwei ZHANG Yuanfu WU Jinguang 《中国科学B辑(英文版)》2005,48(2)
The application of molecular spectroscopy inthe biological fields is more and more extensive.Recently vibrational spectroscopy, including FTIRATR Optic Fibers[1—3], FT-IR microspectroscopy[4—6],FT-Raman[7,8] and near IR spectroscopic[9] methods,was used… 相似文献
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Yizhuang?Xu Limin?Yang Zhi?Xu Ying?Zhao Xiaofeng?Ling Qingbo?Li Jiansheng?Wang Nengwei?Zhang Yuanfu?Zhang Jinguang?WuEmail author 《中国科学B辑(英文版)》2005,48(2):167-175
Gastric tissue samples were studied using mid-IR fiber-optic attenuated total reflectance (ATR) spectroscopy. FTIR spectra
of 90 tissue samples from 48 patients, including 32 normal and 58 malignant tissue samples, were chosen as examples. Malignancy
was usually characterized by the absence of CH and C=O bands, a weak amide II band near 1545 cm-1, a shift of the amide I band to lower wave number, a decrease in the ∼1450 cm-1 peak to less than the ∼ 1400 cm-1 peak. Subtraction spectra indicate that the amide I and amide II bands of normal and malignant tissues have larger differences
in peak positions and relative intensities. The statistical analysis results confirm this conclusion. The results indicate
that FTIR fiber optic techniques provide important information about cancerous tissue of the stomach, which can be used to
differentiate the malignant tissue from the normal tissue. Based on the above results we successfully realize the detection
of the tumor tissues of digestive tract in vivo and in situ. And the results of detection cancer near operating room and in vivo and in situ in the operating room are consistent with the conclusions for the samples stored in liquid N2, which is the basis for the clinical application. 相似文献
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