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Hai‐Qun Gong Quan‐Xiang Wu Lei‐Lei Liu Jun‐Li Yang Rui Wang Yan‐Ping Shi 《Helvetica chimica acta》2011,94(7):1269-1276
Fourteen sesquiterpenoids with an eudesmane C‐atom skeleton, including four new ones, (1β,5α,7β,8β,11β)‐5‐hydroperoxy‐1‐hydroxyeudesm‐4(15)‐eno‐12,8‐lactone ( 1 ), (1β,5α,7β,8β)‐8‐(acetyloxy)‐5‐hydroperoxy‐1‐hydroxycostic acid methyl ester ( 12 ), and a mixture of (1β,3β,4β,7β,8β)‐1,3‐dihydroxyeudesma‐5,11(13)‐dieno‐12,8‐lactone ( 7 ) and (1β,3β,4β,7β,8β,11β)‐1,3‐dihydroxyeudesm‐5‐eno‐12,8‐lactone ( 8 ), were isolated from the aerial parts of Inula japonica (Asteraceae). Their structures were determined by extensive spectroscopic methods, and those of 7 and 12 confirmed by means of single‐crystal X‐ray diffraction analysis. 相似文献
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The four diastereoisomeric gorgonane sesquiterpenes 1 – 4 and the two diastereoisomeric forfugane sesquiterpenes 6 and 7 , which all have the same molecular formula C15H28O3 and belong to the same eudesmane‐like sesquiterpenes, were isolated from the leaves and twigs of Illicium spathulatum. Their structures were elucidated by spectroscopic methods, including 1D‐ and 2D‐NMR spectroscopy. 相似文献
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Xiao‐Ning Wang Cheng‐Qi Fan Sheng Yin Li‐Ping Lin Jian Ding Jian‐Min Yue 《Helvetica chimica acta》2008,91(3):510-519
Three new triterpenoids, turrapubesols A–C ( 1 – 3 ), and one new sesquiterpenoid, 1α,4α‐dihydroxyeudesman‐11‐ene ( 4 ), along with 12 known terpenoids were isolated from Turraea pubescens. The structures of the terpenoids were established on the basis of extensive spectroscopic analyses and by a chemical transformation. The previous assignment of the NMR data for guaidiol ( 5 ) was corrected. Some of the triterpenoids exhibited cytotoxicity against the P‐388 cell line. 相似文献
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Investigation of unpolar extracts from the aerial parts of Senecio argunensis afforded two new sesquiterpenoids, 1β‐hydroxyeudesma‐4,11‐dien‐15‐al ( 1 ) and 4(15)‐cadinene‐5α,10α‐diol, ( 2 ) as well as six known compounds, 3 – 8 . The structures of all isolates were elucidated on the basis of extensive analyses of spectroscopic data and comparison with literature data. 相似文献
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Five new compounds were isolated from the roots of Ligularia dentata, including four bisabolane‐type sesquiterpenoids, 1 – 4 , as well a new eudesmane, 5 . The previously isolated 3α,6α,9‐tris(angeloyloxy)‐2α,4β‐dihydroxy‐7,11‐epoxybisabol‐10(15)‐en‐5‐one ( 6 ), when left as an oil in a refrigerator over nine months, gave rise to a mixture of two positional isomers, 7 and 8 . Their formation is rationalized by means of epoxide ring opening and shift of an angeloyl (Ang) group. The structures of compounds 1 – 5, 7 , and 8 were established by in‐depth spectroscopic (UV, CD, IR, 1D‐ and 2D‐NMR) as well as mass‐spectrometric methods. 相似文献
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Zhi‐Jun Zhang Juan He Yan Li Xing‐De Wu Xiu Gao Li‐Yan Peng Xiao Cheng Rong‐Tao Li Qin‐Shi Zhao 《Helvetica chimica acta》2013,96(4):732-737
A new eremophilane sesquiterpene, (2β)‐2‐deoxo‐2‐methoxytessaric acid ( 1 ), and two new eudesmane sesquiterpenes, (3β,10α)‐3‐methoxyleudesma‐4,11(13)‐dien‐12‐oic acid ( 2 ) and (3α,4β,8α)‐4‐(acetyloxy)‐3‐(2,3‐dihydroxy)‐2‐methyl‐1‐oxobutoxy‐8‐hydroxyeudesm‐7(11)‐eno‐12,8‐lactone ( 3 ), along with the ten known compounds 4 – 13 were isolated from the aerial parts of Laggera pterodonta. The structures of the new compounds were elucidated by spectroscopic analyses, including 2D‐NMR data. 相似文献
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Wen‐Jian Lan Hong‐Ping Wan Guo‐Xi Li Hou‐Jin Li Yun‐Yun Chen Cheng‐Zhu Liao Ji‐Wen Cai 《Helvetica chimica acta》2008,91(3):426-434
Chemical investigation of an extract of the marine sponge Axinyssa sp., collected from the South China Sea, led to the isolation and identification of two new sesquiterpene formamides, (4R*,5R*,10R*)‐4‐formamidoeudesm‐7‐ene ( 1 ) and (4R*,5R*,7S*,10R*)‐4‐formamidoeudesman‐11‐ol ( 2 ), together with the known 4α‐formamidogorgon‐11‐ene ( 3 ). Their structures were elucidated by spectroscopic methods, including 1D‐ and 2D‐NMR spectroscopy, high‐resolution ESI‐TOF mass spectrometry, as well as X‐ray single‐crystal diffraction experiments. Possible biosynthetic pathways for 1 – 3 were also proposed. The human nasopharyngeal cancer cell line CNE‐2, human cervical cancer cell line HeLa, and human normal liver cell line L02 were used to examine the cytotoxic activities of 1 – 3 in vitro. As the results, 1 showed significant cytotoxic activity against CNE‐2, HeLa, and L02 cell lines with the IC50 values of 13.8, 7.5, and 38.0 μg/ml, resp. 相似文献
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