Quantitative Analysis of Uncoated Eszopiclone Tablets by Near-Infrared Spectroscopy

This study employed near-infrared (NIR) spectroscopy to analyze content uniformity, moisture content, compression force, tablet hardness, average particle size, and particle-size distribution. The content uniformity, moisture content, compression force, tablet hardness, and average particle size models yielded high correlation coefficients (R²) of 0.99582, 0.99725, 0.99620, 0.96294, and 0.98421, respectively, whereas the particle size distribution models showed good predictive ability. Conventional criteria such as R², root-mean-square error of calibration, and the root-mean-square error of prediction were used to evaluate the accuracy and precision of the model. To ensure the accuracy and predictability of the content model for low-dose tablets, additional validation and reliability evaluations were performed using 70%, 80%, 100%, 120%, and 130% drug concentrations as well as 90% and 110% active content formulations. Near-infrared spectroscopy with multivariate modeling is a rapid, nondestructive technique for the characterization of the manufacturing process.     

Economic Electrochemical Sensors for the Determination of Eszopiclone in Pharmaceutical Formulation with Greenness Profile Assessment

Electrochemical-ion-selective-sensors offer green, rapid, economic and simple analytical-tool in pharmaceutical industry, control processes, physiological measurements and environmental monitoring. In this study, two sensors were introduced for eszopiclone (EZP) determination in pure-form and in pharmaceutical-dosage-forms using drug-ion-exchanger association complex fabrication technique. Two different ion-exchangers were used and compared, tetrakis (4-chlorophenyl) borate in sensor1 and tetraphenyl borate in sensor 2. Such sensors showed superior performance at pH 3.5 over a wide-range of EZP concentration. The proposed method was also assessed using GAPI and analytical Eco-scale. Low cost, short analysis-time, simplicity and greenness of the proposed sensors allow their use for high-through-put analysis in quality-control laboratories.